[AMPK信号通道调控自噬和线粒体平衡的研究进展]。

Q3 Medicine
Peisen Ruan, Yao Zheng, Zhuoya Dong, Yan Wang, Ya'nan Xu, Hehe Chen
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引用次数: 0

摘要

AMP 激活蛋白激酶(AMPK)是真核细胞中分布广泛、进化保守的丝氨酸/苏氨酸蛋白激酶。在调节细胞能量代谢方面,AMPK 作为能量代谢激酶发挥着极其重要的作用。当机体处于低能量状态时,AMPK 会随着细胞内腺嘌呤核苷酸水平的变化而被激活,并与单磷酸腺苷(AMP)或二磷酸腺苷(ADP)结合。活化的 AMPK 可调节各种代谢过程,包括脂质和葡萄糖代谢以及细胞自噬。AMPK 通过磷酸化哺乳动物雷帕霉素靶复合物 1(mTORC1)、丝氨酸/苏氨酸蛋白激酶失调 51 型激酶 1(ULK1)和 III 型磷脂酰肌醇 3- 激酶-空泡蛋白分选 34(PIK3C3-VPS34)复合物中与自噬相关的蛋白,直接促进自噬。AMPK 还能调节转录因子(如叉头盒 O3(FOXO3)、溶酶体功能转录因子 EB(TFEB)和溴域蛋白 4(BRD4))下游自噬相关基因的表达,从而间接促进自噬。AMPK 还能调节线粒体自噬,诱导受损线粒体分裂,并促进自噬反应向受损线粒体转移。AMPK 的另一个功能是通过刺激线粒体生物生成和参与线粒体平衡调节的各个方面来调节线粒体健康。这篇综述讨论了 AMPK 信号通路对线粒体生物学和内环境稳态的特定调节,认为它是细胞应对能量压力和调节线粒体的核心,强调了 AMPK 在调节细胞自噬和线粒体自噬中的关键作用,以及线粒体稳态调节研究的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Research progress in the regulation of autophagy and mitochondrial homeostasis by AMPK signaling channels].

AMP-activated protein kinase (AMPK) is a widely distributed and evolutionarily conserved serine/threonine protein kinase present in eukaryotic cells. In regulating cellular energy metabolism, AMPK plays an extremely important role as an energy metabolic kinase. When the body is in a low energy state, AMPK is activated in response to changes in intracellular adenine nucleotide levels and is bound to adenosine monophosphate (AMP) or adenosine diphosphate (ADP). Activated AMPK regulates various metabolic processes, including lipid and glucose metabolism and cellular autophagy. AMPK directly promotes autophagy by phosphorylating autophagy-related proteins in the mammalian target of rapamycin complex 1 (mTORC1), serine/threonine protein kinase-dysregulated 51-like kinase 1 (ULK1) and type III phosphatidylinositol 3-kinase-vacuolar protein-sorting 34 (PIK3C3-VPS34) complexes. AMPK also indirectly promotes autophagy by regulating the expression of downstream autophagy-related genes of transcription factors such as forkhead box O3 (FOXO3), lysosomal function transcription factor EB (TFEB) and bromodomain protein 4 (BRD4). AMPK also regulates mitochondrial autophagy, induces the division of damaged mitochondria and promotes the transfer of the autophagic response to damaged mitochondria. Another function of AMPK is to regulate mitochondrial health by stimulating mitochondrial biogenesis and participating in various aspects of mitochondrial homeostasis regulation. This review discusses the specific regulation of mitochondrial biology and internal environmental homeostasis by AMPK signaling channels as central to the cellular response to energy stress and regulation of mitochondria, highlighting the key role of AMPK in regulating cellular autophagy and mitochondrial autophagy, as well as advances in research on the regulation of mitochondrial homeostasis.

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来源期刊
Zhonghua wei zhong bing ji jiu yi xue
Zhonghua wei zhong bing ji jiu yi xue Medicine-Critical Care and Intensive Care Medicine
CiteScore
1.00
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0.00%
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42
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