胸膜间皮瘤和腹膜间皮瘤 MTAP 缺失的不同频率和临床作用

IF 1.3 4区 医学 Q3 ANATOMY & MORPHOLOGY
Ben Davidson, Arild Holth, Charlotte Hummel, Kjersti Flatmark, Annette Torgunrud
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引用次数: 0

摘要

本研究旨在分析甲硫腺苷磷酸化酶(MTAP)在间皮瘤中的表达和预后作用。通过免疫组化方法分析了113例间皮瘤(60例胸膜瘤和53例腹膜瘤)中MTAP蛋白的表达情况,其中包括36例渗出液和77例手术标本。38 例肿瘤中 MTAP 表达完全丧失,8 例部分丧失。与活检/手术切除标本相比(20/36 对 26/77;P=0.017),与腹膜间皮瘤相比(35/60 对 11/53;P=0.017),渗出液中的 MTAP 表达明显更常见。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Different Frequency and Clinical Role for MTAP Loss in Pleural and Peritoneal Mesothelioma.

The objective of this study was to analyze the expression and prognostic role of methylthioadenosine phosphorylase (MTAP) in mesothelioma. MTAP protein expression by immunohistochemistry was analyzed in 113 mesotheliomas (60 pleural and 53 peritoneal), consisting of 36 effusions and 77 surgical specimens. MTAP expression was fully lost in 38 tumors and partially lost in 8 tumors. Loss of expression was significantly more common in effusions compared with biopsies/surgical resection specimens (20/36 vs. 26/77; P =0.017), and in pleural compared with peritoneal mesotheliomas (35/60 vs. 11/53; P <0.001). MTAP performed less robustly than BAP1 in comparative analysis of 57 tumors previously analyzed for expression of the latter protein (46 vs. 25 cases with loss of expression). In survival analysis for 69 patients with partial clinical data, male gender was significantly associated with shorter overall survival (OS; P =0.042), whereas loss of MTAP was associated with a trend for shorter OS ( P =0.058), with no prognostic role for patient age ( P =0.379) or anatomic site ( P =0.381). The association between loss of MTAP and poor OS became significant when survival analysis was limited to patients with pleural mesothelioma ( P =0.018). In conclusion, loss of MTAP expression is more frequent in pleural compared with peritoneal mesothelioma and has limited diagnostic relevance at the latter anatomic site. More frequent loss in effusion specimens suggests a role for this marker in effusion cytology. MTAP loss in pleural mesothelioma is associated with poor survival.

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来源期刊
Applied Immunohistochemistry & Molecular Morphology
Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY
CiteScore
3.20
自引率
0.00%
发文量
153
期刊介绍: ​Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology​.
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