Correction to “Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox–Gastaut syndrome: Interim analysis of an open-label extension study”

Knupp KG, Scheffer IE, Ceulemans B, et al. Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox–Gastaut syndrome: Interim analysis of an open-label extension study. Epilepsia. 2023;64(1):139–151. doi:10.1111/epi.17431

In Paragraph 2 on page 145 of Section 3.3 (“Effectiveness”) of the “Results” section, the following sentences contained data describing typical, non-ESC-confirmed drop seizures:

“In the overall treatment period, median percentage increase in days free of drop seizures was 41.6% compared to pretreatment baseline in the core RCT, with a median absolute change of 1.93 days per 28 days (range = −23.0 to 27.5 days; p < .0001). The longest interval between drop seizures increased from a median of 2.0 days (range = 1–17 days) to a median of 6.0 days (range = 1–365 days).”

The data ‘41.6%’, ‘1.93 days’, ‘27.5 days’, and ‘6.0 days’ needs to be updated for consistency with the data reported in the rest of the manuscript. The data in this paragraph should be updated to ESC-confirmed drop seizures, as shown below:

“In the overall treatment period, median percentage increase in days free of drop seizures was 44.6% compared to pretreatment baseline in the core RCT, with a median absolute change of 2.03 days per 28 days (range = −23.0 to 27.8 days; p < .0001). The longest interval between drop seizures increased from a median of 2.0 days (range = 1–17 days) to a median of 7.0 days (range = 1–365 days).”

The data ‘41.6%’ becomes ‘44.6%’, ‘1.93 days’ becomes ‘2.03 days’, ‘27.5 days’ becomes ‘27.8 days’, and ‘6.0 days’ becomes ‘7.0 days’.

In Table 2 on page 144 of Section 3.2 of the “Results”, the text “.3 to .5” should be “.3 to <.5”. In the next row, the text “>.5 to .7” should be “≥.5 to .7”.

In the first paragraph of Section 3.2 of the “Results” on page 144, line 5, the text “.3 - .5 mg/kg/day” should be “.3 - <.5 mg/kg/day”.

We confirm that these corrections do not change the interpretation of our results. We apologize for these errors.