微生物中活性吲哚生物碱的研究进展

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC
Bing Liu, Lijing Zhang, Ting Zhu, Yuxin Wang, Ning Chen, Wenlan Li, Ting Li
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引用次数: 0

摘要

::吲哚生物碱是一类具有广泛生物活性的次级代谢产物。吲哚生物碱的化学结构相对复杂,但它们都有一个显著的结构特征,那就是都有一个五元吡咯环。由于吲哚生物碱独特的结构特点,它们还具有广泛的药理活性,如抗菌、抗炎、抗肿瘤、抗病毒、抗肝炎、抗糖尿病、神经保护、降血脂等。例如,吲哚生物碱通过各种抗增殖机制显示出抗癌活性,在新型癌症治疗进展的研究中发挥着重要作用。本文综述了近年来从微生物中分离出的吲哚生物碱及其化学和生物合成的研究进展,为进一步利用和开发吲哚生物碱奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Progress on Active Indole Alkaloids in Microorganisms
:: Indole alkaloids are a class of secondary metabolites with a wide range of biological activities. The chemical structure of indole alkaloids is relatively complex, but all of them have a remarkable structural feature, which is a five-membered pyrrole cyclocyclobenzene ring. Because of the unique structural characteristics of indole alkaloids, they have also a wide range of pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor, anti-viral, anti-hepatitis, antidiabetes, neuroprotective, lipid-lowering and so on. For example, indole alkaloids have been shown to show anticancer activity through various anti-proliferation mechanisms and play an important role in the research of novel cancer treatment advances. In this article, we reviewed the recent progress of indole alkaloids isolated from microorganisms and their chemical and biosynthesis, which laid a foundation for further utilization and development of indole alkaloids.
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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