粘弹性参数和壁厚对颈动脉壁运动的影响分析及其临床应用

IF 1.9 4区 工程技术 Q2 Engineering
Duc-Manh Dinh, Jeong-Seop Shin, Eui-Young Choi, Kyehan Rhee
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引用次数: 0

摘要

了解血管疾病进展过程中动脉壁粘弹性的变化至关重要。然而,对粘弹性参数的评估及其对桡动脉壁运动的影响一直缺乏全面的研究。为了弥补这一不足,我们基于薄壁管假设,通过求解标准线性模型(SLM)的粘弹性构成方程来分析桡骨波形。此外,我们还采用有限元法(FEM)模拟了较厚管壁的径向管壁运动。解析解表明,时间常数(\({\tau }_{\varepsilon }\ )值小于 0.05 秒的平衡良好的 SLM 模型能有效模拟人体颈动脉桡侧壁运动的动态响应。有限元结果表明,壁厚增加会导致桡动脉波形振幅减小,而对相位滞后的影响很小。为了评估动脉壁粘弹性的临床相关性,使用优化技术根据每位患者的压力和直径波形估算了 SLM 的粘弹性参数。根据心血管疾病风险状况对 105 名患者进行了分类,并对不同组别的粘弹性参数进行了统计比较。结果显示,高危组的动脉壁弹性明显高于低危组(p < 0.03),而中危组的动脉壁粘度高于低危组(p < 0.01)。因此,动脉壁弹性有望成为区分低风险组和高风险组的重要指标,而粘度则有望成为区分低风险组和中风险组的重要指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Analysis of the Effects of Viscoelastic Parameters and Wall Thickness on Carotid Wall Motion and Its Clinical Application

Analysis of the Effects of Viscoelastic Parameters and Wall Thickness on Carotid Wall Motion and Its Clinical Application

Understanding the changes in arterial wall viscoelasticity during the progression of vascular disease is crucial. Nonetheless, there has been a lack of comprehensive investigation into the assessment of viscoelastic parameters and their impact on radial wall motion. To address this gap, we analyzed the radius waveform by solving the viscoelastic constitutive equations of the standard linear model (SLM) based on a thin-wall tube assumption. Additionally, a finite element method (FEM) was applied to simulate radial wall motion for thicker walls. The analytic solution showed that a well-balanced SLM model with the time constant (\({\tau }_{\varepsilon }\)) values smaller than 0.05 s could effectively simulate the dynamic response of radial wall motion in a human carotid artery. FEM result showed that increasing wall thickness led to a decrease in the amplitude of the radius waveform, while its effect on phase lag was marginal. To evaluate the clinical relevance of arterial wall viscoelasticity, the viscoelastic parameters of the SLM were estimated from the pressure and diameter waveforms of each patient using an optimization technique. The 105 patients were categorized according to their cardiovascular disease risk status, and statistical comparisons were made for viscoelastic parameters across the different groups. The results revealed that the high-risk group exhibited significantly higher wall elasticity than the low-risk group (p < 0.03), while the intermediate-risk group demonstrated higher wall viscosity than the low-risk group (p < 0.01). Therefore, arterial wall elasticity holds potential as a significant indicator for distinguishing between low-risk and high-risk groups, whereas viscosity shows promise as a significant indicator for distinguishing between low-risk and intermediate-risk groups.

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来源期刊
CiteScore
4.10
自引率
10.50%
发文量
115
审稿时长
3-6 weeks
期刊介绍: The International Journal of Precision Engineering and Manufacturing accepts original contributions on all aspects of precision engineering and manufacturing. The journal specific focus areas include, but are not limited to: - Precision Machining Processes - Manufacturing Systems - Robotics and Automation - Machine Tools - Design and Materials - Biomechanical Engineering - Nano/Micro Technology - Rapid Prototyping and Manufacturing - Measurements and Control Surveys and reviews will also be planned in consultation with the Editorial Board.
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