Laurel Stell, Kent Heberer, Kyung Min Lee, Shoa Clarke, Wu Fan, Ilana Belitskaya-Levy, Julie A. Lynch, Hua Tang, Marijana Vujkovic, Donald Miller, Themistocles L. Assimes, Phil Tsao, Scott Damrauer, Kyong-mi Chang, Jennifer S. Lee, the VA Million Veteran Program
{"title":"非血糖基因对非洲血统 HbA1c 和临床血糖状况的影响：退伍军人协会百万退伍军人计划","authors":"Laurel Stell, Kent Heberer, Kyung Min Lee, Shoa Clarke, Wu Fan, Ilana Belitskaya-Levy, Julie A. Lynch, Hua Tang, Marijana Vujkovic, Donald Miller, Themistocles L. Assimes, Phil Tsao, Scott Damrauer, Kyong-mi Chang, Jennifer S. Lee, the VA Million Veteran Program","doi":"10.1101/2024.05.26.24307947","DOIUrl":null,"url":null,"abstract":"<strong>IMPORTANCE</strong> Clinical guidelines recommend against using glycated hemoglobin A1c (HbA1c) to assess glycemia in patients with two erythropoietic conditions: glucose-6-phosphate dehydrogenase (G6PD) deficiency or sickle cell disease. What remains elusive is quantifying the impact of genetic variants underlying these and other erythropoietic conditions on HbA1c levels as a clinical indicator of glycemic status.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"35 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-glycemic genetic effects on HbA1c and clinical glycemic status in African ancestry: VA Million Veteran Program\",\"authors\":\"Laurel Stell, Kent Heberer, Kyung Min Lee, Shoa Clarke, Wu Fan, Ilana Belitskaya-Levy, Julie A. Lynch, Hua Tang, Marijana Vujkovic, Donald Miller, Themistocles L. Assimes, Phil Tsao, Scott Damrauer, Kyong-mi Chang, Jennifer S. Lee, the VA Million Veteran Program\",\"doi\":\"10.1101/2024.05.26.24307947\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>IMPORTANCE</strong> Clinical guidelines recommend against using glycated hemoglobin A1c (HbA1c) to assess glycemia in patients with two erythropoietic conditions: glucose-6-phosphate dehydrogenase (G6PD) deficiency or sickle cell disease. What remains elusive is quantifying the impact of genetic variants underlying these and other erythropoietic conditions on HbA1c levels as a clinical indicator of glycemic status.\",\"PeriodicalId\":501419,\"journal\":{\"name\":\"medRxiv - Endocrinology\",\"volume\":\"35 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.05.26.24307947\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.05.26.24307947","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Non-glycemic genetic effects on HbA1c and clinical glycemic status in African ancestry: VA Million Veteran Program
IMPORTANCE Clinical guidelines recommend against using glycated hemoglobin A1c (HbA1c) to assess glycemia in patients with two erythropoietic conditions: glucose-6-phosphate dehydrogenase (G6PD) deficiency or sickle cell disease. What remains elusive is quantifying the impact of genetic variants underlying these and other erythropoietic conditions on HbA1c levels as a clinical indicator of glycemic status.
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