使用开口式涂抹器测定千伏 X 射线治疗深度剂量。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-09-01 Epub Date: 2024-05-28 DOI:10.1007/s13246-024-01439-4
Anne Perkins, Brendan Healy, Ben Coldrey
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引用次数: 0

摘要

这项工作的目的是确定 WOmed-T105 设备发出的千伏 X 射线的深度剂量百分比 (PDD) 曲线,该设备采用开口钢制涂抹器,光束质量为 0.5 至 4.2 毫米 Al。在水模型中使用平行板室进行测量,根据五阶多项式进行外推法估算表面剂量。此外,还在塑料水模型中使用平行板室进行了测量,并使用薄塑料片获得浅层(小于 1 毫米)的详细测量结果。使用 EGSnrc 软件包进行蒙特卡罗模拟,输入两种不同的数据源:X 射线束的 SpekPy 模拟和 X 射线管、治疗头和涂抹器的完全模拟。结果表明,所有四种方法(两种测量和两种模拟)在深度大于 2 毫米时的测量不确定性都一致。在深度较浅的情况下,则存在明显差异。在深度小于 0.1 毫米时,完整的蒙特卡罗模拟和固体水测量结果显示表面剂量急剧上升,这归因于电子污染,而 SpekPy 蒙特卡罗模拟和推断的水测量结果均未显示出电子污染。在 0.1 毫米到 2 毫米的深度(超出电子污染范围),外推水测量结果比蒙特卡罗模拟和固态水测量结果低估了 13% 的剂量,这归因于涂抹器中产生的荧光光子。这项工作表明,对于开口式涂抹器,通过外推表面剂量来测量水中的深度剂量有可能会大大低估表面至 2 毫米之间浅层的剂量,即使在消除了光束的电子污染之后也是如此。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Determination of kilovoltage x-ray therapy depth doses with open-ended applicators.

Determination of kilovoltage x-ray therapy depth doses with open-ended applicators.

The purpose of this work was to determine percentage depth dose (PDD) curves for kilovoltage x-rays from the WOmed-T105 unit, with open-ended steel applicators and beam qualities ranging from 0.5 to 4.2 mm Al. Measurements were made with parallel plate chambers in a water phantom, with extrapolation based on a fifth order polynomial used to estimate the surface dose. Measurements were also made with parallel plate chambers in a plastic water phantom, with thin plastic sheets used to obtain detailed measurements at shallow depths (less than 1 mm). Monte Carlo simulations were performed using the EGSnrc package, with two different sources as input: a SpekPy simulation of the x-ray beam and a full simulation of the x-ray tube, treatment head and applicators. Results showed that all four methods (two measurements and two simulations) agreed within the measurement uncertainty at depths greater than 2 mm. At shallow depths, significant differences were noted. At depths less than 0.1 mm, the full Monte Carlo simulation and the solid water measurements showed a sharp spike in surface dose which is attributed to electron contamination, which was not seen in the SpekPy Monte Carlo simulation or the extrapolated water measurements. At depths between 0.1 mm and 2 mm, beyond the range of contaminant electrons, the extrapolated water measurements underestimate the dose by up to 13% compared to the full Monte Carlo simulation and the solid water measurements, attributed to fluorescent photons generated in the applicators. This work demonstrates that for open-ended applicators, measurement of depth doses in water with extrapolation of surface dose has the potential to significantly underestimate the dose at shallow depths between the surface and 2 mm, even after eliminating electron contamination from the beam.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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