无神经精神症状的系统性红斑狼疮患者白质的微结构变化:多壳弥散成像研究。

IF 4.9 2区 医学 Q1 Medicine
Wenjun Hu, Ziru Qiu, Qin Huang, Yuhao Lin, Jiaying Mo, Linhui Wang, Jingyi Wang, Kan Deng, Yanqiu Feng, Xinyuan Zhang, Xiangliang Tan
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引用次数: 0

摘要

背景:与单壳弥散张量成像(DTI)相比,弥散峰度成像(DKI)和神经元定向弥散和密度成像(NODDI)能更全面、更翔实地透视脑白质(WM)的微观结构改变,尤其是在检测交叉纤维方面。然而,针对无神经精神症状的系统性红斑狼疮患者(非 NPSLE 患者)使用多壳弥散成像的研究仍然很少:方法:49 名非非系统性红斑狼疮患者和 41 名年龄、性别和教育程度相匹配的健康对照者接受了多壳弥散磁共振成像。共评估了 10 项基于 DKI(分数各向异性、平均扩散率、轴向扩散率、径向扩散率、平均峰度、轴向峰度和径向峰度)和 NODDI(神经元密度指数、定向弥散指数和各向同性扩散区的体积分数)的扩散指标。为确定脑WM微观结构的组间差异,还进行了基于肽段的空间统计(TBSS)和基于图谱的感兴趣区(ROI)分析。多壳扩散指标与临床指标的关系有待进一步研究:结果:TBSS分析表明,非NPSLE患者的WM中FA、AD和RK减少,ODI增加(P 结论:该研究表明,DKI和NPSLE患者的WM微观结构存在差异:这项研究表明,DKI 和 NODDI 指标可以互补地检测非 NPSLE 患者的 WM 异常,并揭示了 ODI 是比 DKI 更敏感、更特异的生物标志物,这将有助于进一步了解系统性红斑狼疮正常表现 WM 损伤的病理生理机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microstructural changes of the white matter in systemic lupus erythematosus patients without neuropsychiatric symptoms: a multi-shell diffusion imaging study.

Background: Diffusion kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) provide more comprehensive and informative perspective on microstructural alterations of cerebral white matter (WM) than single-shell diffusion tensor imaging (DTI), especially in the detection of crossing fiber. However, studies on systemic lupus erythematosus patients without neuropsychiatric symptoms (non-NPSLE patients) using multi-shell diffusion imaging remain scarce.

Methods: Totally 49 non-NPSLE patients and 41 age-, sex-, and education-matched healthy controls underwent multi-shell diffusion magnetic resonance imaging. Totally 10 diffusion metrics based on DKI (fractional anisotropy, mean diffusivity, axial diffusivity, radial diffusivity, mean kurtosis, axial kurtosis and radial kurtosis) and NODDI (neurite density index, orientation dispersion index and volume fraction of the isotropic diffusion compartment) were evaluated. Tract-based spatial statistics (TBSS) and atlas-based region-of-interest (ROI) analyses were performed to determine group differences in brain WM microstructure. The associations of multi-shell diffusion metrics with clinical indicators were determined for further investigation.

Results: TBSS analysis revealed reduced FA, AD and RK and increased ODI in the WM of non-NPSLE patients (P < 0.05, family-wise error corrected), and ODI showed the best discriminative ability. Atlas-based ROI analysis found increased ODI values in anterior thalamic radiation (ATR), inferior frontal-occipital fasciculus (IFOF), forceps major (F_major), forceps minor (F_minor) and uncinate fasciculus (UF) in non-NPSLE patients, and the right ATR showed the best discriminative ability. ODI in the F_major was positively correlated to C3.

Conclusion: This study suggested that DKI and NODDI metrics can complementarily detect WM abnormalities in non-NPSLE patients and revealed ODI as a more sensitive and specific biomarker than DKI, guiding further understanding of the pathophysiological mechanism of normal-appearing WM injury in SLE.

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来源期刊
CiteScore
8.60
自引率
2.00%
发文量
261
审稿时长
14 weeks
期刊介绍: Established in 1999, Arthritis Research and Therapy is an international, open access, peer-reviewed journal, publishing original articles in the area of musculoskeletal research and therapy as well as, reviews, commentaries and reports. A major focus of the journal is on the immunologic processes leading to inflammation, damage and repair as they relate to autoimmune rheumatic and musculoskeletal conditions, and which inform the translation of this knowledge into advances in clinical care. Original basic, translational and clinical research is considered for publication along with results of early and late phase therapeutic trials, especially as they pertain to the underpinning science that informs clinical observations in interventional studies.
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