铜催化不对称 Kinugasa/Michael 加成级联反应合成手性螺 β-内酰胺。

IF 5 1区 化学 Q1 CHEMISTRY, ORGANIC
Yunlin Ao, Haowen Ma, Binghan Gan, Wenjing Wang, Jiehao Zhang, Wei Zhou, Xiaoqi Zhang* and Qian Cai*, 
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引用次数: 0

摘要

该研究开发了一种温和的铜催化不对称 Kinugasa/Michael 加成级联过程。α、β-不饱和酯拴丙炔酰胺与硝基化合物的反应为构建功能化手性 2,6-二氮杂螺[3.4]辛烷-1,5-二酮产品提供了一个高效的方案,该方案产率令人满意,并具有很高的对映和非对映选择性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Copper-Catalyzed Asymmetric Kinugasa/Michael Addition Cascade Reactions for the Synthesis of Chiral Spiro β-Lactams

Copper-Catalyzed Asymmetric Kinugasa/Michael Addition Cascade Reactions for the Synthesis of Chiral Spiro β-Lactams

Copper-Catalyzed Asymmetric Kinugasa/Michael Addition Cascade Reactions for the Synthesis of Chiral Spiro β-Lactams

A mild copper-catalyzed asymmetric Kinugasa/Michael addition cascade process is developed. The reaction of α, β-unsaturated ester-tethered propiolamides with nitrones provides an efficient protocol for the construction of functionalized chiral 2,6-diazaspiro[3.4]octane-1,5-dione products in satisfactory yields and with high enantio- and diastereoselectivities.

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来源期刊
Organic Letters
Organic Letters 化学-有机化学
CiteScore
9.30
自引率
11.50%
发文量
1607
审稿时长
1.5 months
期刊介绍: Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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