用于增强腹部疝气修复愈合的永久性网片涂层:范围审查。

IF 1.2 4区 医学 Q3 SURGERY
Surgical Innovation Pub Date : 2024-08-01 Epub Date: 2024-05-27 DOI:10.1177/15533506241255258
Jason Joe Baker, Jacob Rosenberg
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引用次数: 0

摘要

导言:疝气网被用来降低复发率和疼痛率,但复发率仍然很高。网片涂层可以改善这一状况。本范围综述旨在概述用于促进腹股沟疝修补术愈合的网片涂层,并报告有益和无益的效果:我们纳入了使用非商业涂层网片修复腹部疝气的人类和动物研究。我们检索了 Pubmed、Embase、Cochrane Central、LILACS 和 CNKI,没有语言限制:结果:在已确定的 2933 项研究中,有 58 项被纳入:6 项研究共有 408 人参与,52 项研究共有 2679 只动物参与。中位随访时间为 12 个月(1-156 个月),95% 的疝气为切口疝气。共有44种不同的涂层,包括富血小板血浆、间充质干细胞、生长因子、维生素E、胶原衍生产品、各种多糖、丝蛋白、壳聚糖、庆大霉素、强力霉素、硝基呋喃妥因、钛和类金刚石碳。研究最多的是间充质干细胞和富血小板血浆。间充质干细胞明显减少了炎症和异物反应,但对其他愈合指标没有影响。相比之下,富血小板血浆对组织生长、胶原沉积和新生血管有积极影响,对炎症和异物反应有不同影响:我们发现了44种不同的网状物涂层,它们显示出不同的效果。研究最多的是间充质干细胞和富血小板血浆,后者在改善疝气修复的生物力学特性方面前景广阔。要确定它们在人体中的最终用途,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coatings for Permanent Meshes Used to Enhance Healing in Abdominal Hernia Repair: A Scoping Review.

Introduction: Hernia meshes are used to reduce recurrence and pain rates, but the rates are still high. This could be improved with coatings of the mesh. This scoping review aimed to provide an overview of mesh coatings used to promote healing in abdominal hernia repair and to report beneficial and unbeneficial effects.

Methods: We included human and animal studies with abdominal hernias that were repaired with non-commercially coated meshes. We searched Pubmed, Embase, Cochrane Central, LILACS, and CNKI without language constraints.

Results: Of 2933 identified studies, 58 were included: six studies had a total of 408 humans and 52 studies had 2679 animals. The median follow-up was 12 months (range 1-156), and 95% of the hernias were incisional. There were 44 different coatings which included platelet-rich plasma, mesenchymal stem cells, growth factors, vitamin E, collagen-derived products, various polysaccharides, silk proteins, chitosan, gentamycin, doxycycline, nitrofurantoin, titanium, and diamond-like carbon. Mesenchymal stem cells and platelet-rich plasma were the most researched. Mesenchymal stem cells notably reduced inflammation and foreign body reactions but did not impact other healing metrics. In contrast, platelet-rich plasma positively influenced tissue ingrowth, collagen deposition, and neovascularization and had varying effects on inflammation and foreign body reactions.

Conclusion: We identified 44 different mesh coatings and they showed varying results. Mesenchymal stem cells and platelet-rich plasma were the most studied, with the latter showing considerable promise in improving biomechanical properties in hernia repair. Further investigations are needed to ascertain their definitive use in humans.

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来源期刊
Surgical Innovation
Surgical Innovation 医学-外科
CiteScore
2.90
自引率
0.00%
发文量
72
审稿时长
6-12 weeks
期刊介绍: Surgical Innovation (SRI) is a peer-reviewed bi-monthly journal focusing on minimally invasive surgical techniques, new instruments such as laparoscopes and endoscopes, and new technologies. SRI prepares surgeons to think and work in "the operating room of the future" through learning new techniques, understanding and adapting to new technologies, maintaining surgical competencies, and applying surgical outcomes data to their practices. This journal is a member of the Committee on Publication Ethics (COPE).
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