磷酸化吲哚和含 Trp 的低聚肽的电化学合成。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-05-28 DOI:10.1021/acs.orglett.4c01471

Jian Wang, Zhaoqi Zhang, Yirui Shen, Yufen Zhao and Ju Wu*,

{"title":"磷酸化吲哚和含 Trp 的低聚肽的电化学合成。","authors":"Jian Wang, Zhaoqi Zhang, Yirui Shen, Yufen Zhao and Ju Wu*, ","doi":"10.1021/acs.orglett.4c01471","DOIUrl":null,"url":null,"abstract":"Cp2Fe-mediated electrochemical synthesis of phosphorylated indoles and Trp-containing oligopeptides has been developed, which eliminates the need for external oxidants and yields the desired products in moderate to excellent yields under mild conditions. Importantly, the synthetic applicability was further demonstrated through its easy scalability and the anticancer activity of the product. Remarkably, it presents the first electrochemical protocol to access the phosphorylation of indoles and Trp-containing oligopeptides.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"26 22","pages":"4700–4704"},"PeriodicalIF":5.0000,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Electrochemical Synthesis of Phosphorylated Indoles and Trp-Containing Oligopeptides\",\"authors\":\"Jian Wang, Zhaoqi Zhang, Yirui Shen, Yufen Zhao and Ju Wu*, \",\"doi\":\"10.1021/acs.orglett.4c01471\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cp2Fe-mediated electrochemical synthesis of phosphorylated indoles and Trp-containing oligopeptides has been developed, which eliminates the need for external oxidants and yields the desired products in moderate to excellent yields under mild conditions. Importantly, the synthetic applicability was further demonstrated through its easy scalability and the anticancer activity of the product. Remarkably, it presents the first electrochemical protocol to access the phosphorylation of indoles and Trp-containing oligopeptides.\",\"PeriodicalId\":54,\"journal\":{\"name\":\"Organic Letters\",\"volume\":\"26 22\",\"pages\":\"4700–4704\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2024-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.orglett.4c01471\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.orglett.4c01471","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

我们开发了 Cp2Fe 介导的磷酸化吲哚和含 Trp 寡肽的电化学合成方法，该方法无需外加氧化剂，在温和的条件下就能以中等到极高的产率获得所需的产品。重要的是，该合成方法的易扩展性和产品的抗癌活性进一步证明了其适用性。值得注意的是，它首次提出了电化学方法来实现吲哚和含 Trp 寡肽的磷酸化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electrochemical Synthesis of Phosphorylated Indoles and Trp-Containing Oligopeptides

查看原文本刊更多论文

Electrochemical Synthesis of Phosphorylated Indoles and Trp-Containing Oligopeptides

Cp₂Fe-mediated electrochemical synthesis of phosphorylated indoles and Trp-containing oligopeptides has been developed, which eliminates the need for external oxidants and yields the desired products in moderate to excellent yields under mild conditions. Importantly, the synthetic applicability was further demonstrated through its easy scalability and the anticancer activity of the product. Remarkably, it presents the first electrochemical protocol to access the phosphorylation of indoles and Trp-containing oligopeptides.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.