(±)-恩替卡韦的合成

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2024-05-19 DOI:10.1134/S1070428024030060

Z. R. Valiullina, N. A. Ivanova, M. S. Miftakhov

引用次数: 0

摘要

摘要在科里(±)-内酯二元醇的基础上开发出了(±)-恩替卡韦的实用合成方法。其关键步骤是通过氧化脱羧 2-{(1S*、2-{(1S*,2R*,3S*,5R*)-5-{[叔丁基（二甲基）硅烷基]氧基}-3-(1-乙氧基乙氧基)-2-[(1-乙氧基乙氧基)甲基]环戊基}乙酸与四乙酸铅的氧化脱羧反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of (±)-Entecavir

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Synthesis of (±)-Entecavir

A practical synthesis of (±)-entecavir has been developed on the basis of Corey (±)-lactone diol. The key stage is the synthesis of (1R*,3R*,4S*)-4-(1-ethoxyethoxy)-3-[(1-ethoxyethoxy)methyl]-2-methylidenecyclopentan-1-ol by oxidative decarboxylation of 2-{(1S*,2R*,3S*,5R*)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-(1-ethoxyethoxy)-2-[(1-ethoxyethoxy)methyl]cyclopentyl}acetic acid with lead tetraacetate.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.