基于生物活性 (5Z,9Z)-二十二碳-5,9-二烯酸的酰胺的合成

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2024-05-19 DOI:10.1134/s1070428024030102

E. Kh. Makarova, A. A. Makarov, U. M. Dzhemilev, V. A. D’yakonov

引用次数: 0

摘要

摘要通过Cp2TiCl2催化脂肪族和含氧1,2-二烯的分子间交叉环镁化反应作为关键步骤，合成了(5Z,9Z)-二十二碳-5,9-二烯酸的新型酰胺，它是一种高活性拓扑异构酶I/II抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Amides Based on Biologically Active (5Z,9Z)-Eicosa-5,9-dienoic Acid

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Synthesis of Amides Based on Biologically Active (5Z,9Z)-Eicosa-5,9-dienoic Acid

Abstract

New amides of (5Z,9Z)-eicosa-5,9-dienoic acid, which is a highly active topoisomerase I/II inhibitor, were synthesized via Cp₂TiCl₂-catalyzed intermolecular cross-cyclomagnesiation of aliphatic and oxygen-containing 1,2-dienes as the key step.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.