{"title":"精神分裂症神经炎症的有望标记物","authors":"A. V. Sakharov, S. E. Golygina","doi":"10.1134/s1819712424010185","DOIUrl":null,"url":null,"abstract":"<p><b>Abstract</b>—There is no single model for the pathogenesis of schizophrenia, but neuroinflammation is considered a key mechanism in the development of this disease. The aim of our study was to analyze and summarize the literature data on the role of neuroinflammation markers in schizophrenia. We used the keywords “neuroinflammation,” “cytokines,” “chemokines,” “microcirculation,” “microglia,” “neurodestruction,” and “schizophrenia” to search for the articles published in 1990–2023 in the PubMed and e-Library.ru databases. The review discusses an integrated approach to the concept of neuroinflammation in schizophrenia with regard to known and promising markers. Studies, including those of the authors of the article, indicate a significant role of microcirculation disorders and endothelial dysfunction, cytokines and chemokines, and neurodestruction in the mechanisms of development and course of schizophrenia. The presented results require more detailed studies to establish new neurobiological and pathogenetic functions of neuroinflammation in schizophrenia.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Promising Markers of Neuroinflammation in Schizophrenia\",\"authors\":\"A. V. Sakharov, S. E. Golygina\",\"doi\":\"10.1134/s1819712424010185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Abstract</b>—There is no single model for the pathogenesis of schizophrenia, but neuroinflammation is considered a key mechanism in the development of this disease. The aim of our study was to analyze and summarize the literature data on the role of neuroinflammation markers in schizophrenia. We used the keywords “neuroinflammation,” “cytokines,” “chemokines,” “microcirculation,” “microglia,” “neurodestruction,” and “schizophrenia” to search for the articles published in 1990–2023 in the PubMed and e-Library.ru databases. The review discusses an integrated approach to the concept of neuroinflammation in schizophrenia with regard to known and promising markers. Studies, including those of the authors of the article, indicate a significant role of microcirculation disorders and endothelial dysfunction, cytokines and chemokines, and neurodestruction in the mechanisms of development and course of schizophrenia. The presented results require more detailed studies to establish new neurobiological and pathogenetic functions of neuroinflammation in schizophrenia.</p>\",\"PeriodicalId\":19119,\"journal\":{\"name\":\"Neurochemical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-05-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurochemical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1134/s1819712424010185\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1134/s1819712424010185","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Promising Markers of Neuroinflammation in Schizophrenia
Abstract—There is no single model for the pathogenesis of schizophrenia, but neuroinflammation is considered a key mechanism in the development of this disease. The aim of our study was to analyze and summarize the literature data on the role of neuroinflammation markers in schizophrenia. We used the keywords “neuroinflammation,” “cytokines,” “chemokines,” “microcirculation,” “microglia,” “neurodestruction,” and “schizophrenia” to search for the articles published in 1990–2023 in the PubMed and e-Library.ru databases. The review discusses an integrated approach to the concept of neuroinflammation in schizophrenia with regard to known and promising markers. Studies, including those of the authors of the article, indicate a significant role of microcirculation disorders and endothelial dysfunction, cytokines and chemokines, and neurodestruction in the mechanisms of development and course of schizophrenia. The presented results require more detailed studies to establish new neurobiological and pathogenetic functions of neuroinflammation in schizophrenia.
期刊介绍：
Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components.
The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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