在药物流行病学中使用法国国家健康数据系统（SNDS）：处于成熟阶段的系统回顾

IF 2.2 4区医学 Q3 PHARMACOLOGY & PHARMACY

Therapie Pub Date : 2024-11-01 DOI:10.1016/j.therap.2024.05.003

Olivier Maillard , René Bun , Moussa Laanani , Amandine Verga-Gérard , Taylor Leroy , Nathalie Gault , Candice Estellat , Pernelle Noize , Florentia Kaguelidou , Agnès Sommet , Maryse Lapeyre-Mestre , Annie Fourrier-Réglat , Alain Weill , Catherine Quantin , Florence Tubach

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引用次数: 0

摘要

研究目的法国国家健康数据系统（SNDS）包含覆盖法国 99% 人口（6700 多万人）的医疗保健数据。本研究旨在概述已发表的、在 SNDS 成熟阶段使用该系统进行的药物流行病学研究。方法我们对 2012 年 1 月至 2018 年 8 月期间 Pubmed 和 EMBASE 数据库中的原创研究文章进行了系统性文献综述。结果共纳入 316 篇全文文章，在研究期间每年都有增加。经过筛选，仅有16条记录因未涉及SNDS，而是涉及法国其他医疗数据库而被排除在外。只有 66% 的研究明确报告了研究设计，其中 57% 为回顾性队列研究，22% 为横断面研究。所报告的研究目标是药物利用率（65%）、安全性（22%）和有效性（9%）。几乎所有的 ATC 组别都进行了研究，但涉及神经系统的研究最多，有 149 项（49%），涉及心血管系统药物的有 104 项（34%），涉及全身用抗感染药物的有 50 项（16%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Use of the French National Health Data System (SNDS) in pharmacoepidemiology: A systematic review in its maturation phase

Aim of the study

The French National Health Data System (SNDS) comprises healthcare data that cover 99% of the population (over 67 million individuals) in France. The aim of this study was to present an overview of published pharmacoepidemiological studies using the SNDS in its maturation phase.

Methods

We conducted a systematic literature review of original research articles in the Pubmed and EMBASE databases from January 2012 until August 2018.

Results

A total of 316 full-text articles were included, with an annual increase over the study period. Only 16 records were excluded after screening because they did not involve the SNDS but other French healthcare databases. The study design was clearly reported in only 66% of studies of which 57% were retrospective cohorts and 22% cross-sectional studies. The reported study objectives were drug utilization (65%), safety (22%) and effectiveness (9%). Almost all ATC groups were studied but the most frequent ones concerned the nervous system in 149 studies (49%), cardiovascular system drugs in 104 studies (34%) and anti-infectives for systemic use in 50 studies (16%).

Conclusion

The SNDS is of growing interest for studies on drug use and safety, which could be conducted more in specific populations, including children, pregnant women and the elderly, as these populations are often not included in clinical trials.

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来源期刊

Therapie 医学-药学

CiteScore

3.50

自引率

7.70%

发文量

132

审稿时长

57 days

期刊介绍： Thérapie is a peer-reviewed journal devoted to Clinical Pharmacology, Therapeutics, Pharmacokinetics, Pharmacovigilance, Addictovigilance, Social Pharmacology, Pharmacoepidemiology, Pharmacoeconomics and Evidence-Based-Medicine. Thérapie publishes in French or in English original articles, general reviews, letters to the editor reporting original findings, correspondence relating to articles or letters published in the Journal, short articles, editorials on up-to-date topics, Pharmacovigilance or Addictovigilance reports that follow the French "guidelines" concerning good practice in pharmacovigilance publications. The journal also publishes thematic issues on topical subject. The journal is indexed in the main international data bases and notably in: Biosis Previews/Biological Abstracts, Embase/Excerpta Medica, Medline/Index Medicus, Science Citation Index.