高尿酸血症与心力衰竭急性失代偿:是否存在因果关系?综述

Laura H. Sarieva, S. Nasonova, I. V. Zhirov, Irina A. Zhirova, S. N. Tereshchenko
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引用次数: 0

摘要

心力衰竭急性失代偿问题不仅在俄罗斯,而且在全世界的医疗系统中都具有相关性和重要性,其原因是这部分患者的住院人数显著增加、相关经济成本增加以及预后极差。本文主要探讨心力衰竭急性失代偿的发病机制以及无症状高尿酸血症在这一病症发展过程中的地位。高尿酸血症被认为是心血管疾病患者,尤其是急性心力衰竭失代偿患者预后不良的标志。本文特别强调了药物治疗的方法、黄嘌呤氧化酶抑制剂别嘌呤醇的使用策略、剂量的疗效分析、对预后的影响、实现和控制高尿酸血症目标值的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hyperuricemia and acute decompensation of heart failure: is there a causative link? A review
The relevance and importance of the problem of acute decompensation of heart failure for the health care system not only in Russia, but also in the whole world is caused by a significant increase in the number of hospitalizations, associated increase in financial costs and extremely unfavorable prognosis in this group of patients. The article is devoted to the pathogenesis of acute decompensation of heart failure and the place of asymptomatic hyperuricemia in the development of this condition. Hyperuricemia is considered as a prognostic marker of unfavorable prognosis in patients with both cardiovascular diseases in general and acute decompensation of heart failure in particular. Special emphasis is made on approaches to drug therapy, tactics of xanthine oxidase inhibitor allopurinol use, doses are analyzed in terms of efficacy, influence on prognosis, methods of achieving and controlling target values of hyperuricemia are discussed.
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