肺泡蛋白病:支气管肺泡灌洗经验,当前文献综述

Sercan Aydın, Hasan Yavuz, Ayşegül Çevik Ergönül, Tevfik İlker, K. Turhan, A. Çakan, U. Çağırıcı
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引用次数: 0

摘要

简介:支气管肺泡灌洗术(BAL)被认为是肺泡蛋白沉积症(PAP)的一线治疗方法。我们结合当前的研究对该疾病及其治疗的注意事项进行了回顾,并介绍了我们对 BAL 程序有效性的临床经验。方法:纳入确诊为 PAP 的患者。6 名患者共进行了 15 次 BAL。记录了术前和术后第三小时的动脉血气值。除了氧分压 (PaO2),还评估了与术前值的差值比,并记录了所有患者的灌洗液量。结果:与治疗前相比,PaO2 普遍明显增加。PaO2 变化与每侧灌洗液量之间的相关性被认为是一个显著的结果,尽管统计意义尚未确定。结论观察到 PaO2 变化与灌洗液量呈正相关。这可能预示着,在灌洗液清除后继续灌洗一段时间可提高灌洗过程的质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ALVEOLAR PROTEINOSIS: BRONCHOALVEOLAR LAVAGE EXPERIENCE, CURRENT LITERATURE REVIEW
Introduction: Bronchoalveolar lavage (BAL) is considered as the first-line therapy for pulmonary alveolar proteinosis (PAP). The points to be kept in mind about the disease and its treatment were reviewed with current research and presented together with our clinical experience on the effectiveness of the BAL procedure. Methods: Patients with diagnosis of PAP were included. Total of 15 BALs were applied to 6 patients. Preoperative and 3rd postoperative hour arterial blood gas values were recorded. In addition to the partial oxygen pressures (PaO2), the ratio of the difference to the preoperative value was also evaluated and the lavage volumes of all patients were recorded. Results: A general significant increase in PaO2 was observed compared to pre-treatment. The correlation between the PaO2 change and the lavage volume per side was interpreted as a remarkable result even though statistical significance was not determined. Conclusion: A positive correlation between PaO2 change and lavage volume were observed. This may be a precursor to the idea that continuing lavage for a while after the lavage fluid has cleared improves the quality of the process.
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