A. V. Enert, D. G. Apalkov, S. R. Pereletova, K. V. Trubchenko, T. V. Saprina
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There is insufficient data examining the effect of hypoxia on the progression of complications in patients with DM2. Rhythm disturbances are being actively studied in patients with DM2 in combination with various cardiological problems. Of greatest interest is the study of rhythm disturbances in patients with DM2 without concomitant comorbid conditions of the cardiovascular system, in order to identify early signs of diabetic cardiovascular autonomic neuropathy and cardiomyopathy, as well as additional early risk factors for the development and progression of cardiovascular diseases. Most of the studies are devoted to the study of the association of OSA and various arrhythmias in cardiac patients. However, there is no data on the combined effect of glycemic variability and OSA on the development of cardiac arrhythmias in patients with DM2. 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引用次数: 0
摘要
本综述介绍了 2 型糖尿病(DM2)患者阻塞性睡眠呼吸暂停/呼吸暂停综合征(OSA)、血糖变异性和心律失常三方面的信息。研究分析了流行病学方面、发病关系、可能的仪器和实验室诊断方法以及个性化治疗方法。目前正在指定三联症的某些领域积极开展研究,但尚未发现任何研究包括同时监测反映 DM2 患者这些疾病的指标。许多问题仍存在争议。对 DM2 患者的睡眠障碍进行了积极的研究,但更多的诊断方法是问卷调查,而不是工具性方法。关于缺氧对 DM2 患者并发症进展的影响,目前还没有足够的研究数据。目前正在积极研究合并各种心脏病的 DM2 患者的节律紊乱。最令人感兴趣的是研究没有合并心血管系统疾病的 DM2 患者的心律紊乱,以确定糖尿病心血管自主神经病变和心肌病变的早期征兆,以及心血管疾病发生和发展的早期风险因素。大多数研究都致力于研究 OSA 与心脏病患者各种心律失常之间的关联。然而,目前还没有关于血糖变异和 OSA 对 DM2 患者心律失常发生的综合影响的数据。需要进行更多的研究,以确定 OSA 对 DM2 患者心律失常的影响特征。
Analysis of the contribution of obstructive sleep apnea/hypopnea syndrome and glycemic level variability to the development and progression of cardiac arrhythmias in patients with type 2 diabetes mellitus
In this review, information is presented within the triad: obstructive sleep apnea/hypopnea syndrome (OSA), glycemic variability, and cardiac arrhythmias in patients with type 2 diabetes mellitus (DM2). Epidemiological aspects, pathogenetic relationships, possible instrumental and laboratory diagnostic methods, as well as approaches to personalized therapy are analyzed. Research is being actively conducted in certain areas of the designated triad, however, no studies have been found that include simultaneous monitoring of indicators reflecting these disorders in patients with DM2. Many issues are still controversial. Sleep disturbances in patients with DM2 are actively studied, but more often questionnaires are used for diagnosis, rather than instrumental methods. There is insufficient data examining the effect of hypoxia on the progression of complications in patients with DM2. Rhythm disturbances are being actively studied in patients with DM2 in combination with various cardiological problems. Of greatest interest is the study of rhythm disturbances in patients with DM2 without concomitant comorbid conditions of the cardiovascular system, in order to identify early signs of diabetic cardiovascular autonomic neuropathy and cardiomyopathy, as well as additional early risk factors for the development and progression of cardiovascular diseases. Most of the studies are devoted to the study of the association of OSA and various arrhythmias in cardiac patients. However, there is no data on the combined effect of glycemic variability and OSA on the development of cardiac arrhythmias in patients with DM2. Additional studies are needed to identify the features of the effect of OSA on cardiac arrhythmias in patients with DM2.