An Ensemble Classification Model to Predict Alzheimer’s Incidence as Multiple Classes

This study introduces an ensemble classification model designed to categorize Alzheimer’s disease (AD) into four distinct classes—mild dementia, no dementia, moderate dementia, and very mild dementia—using Magnetic Resonance Imaging (MRI). The proposed model entitled the Ensemble Classification Model to Predict Alzheimer's Incidence as Multiple Classes (PAIMC) that integrates a six-dimensional analysis of MR images, encompassing entropies, Fractal Dimensions, Gray Level Run Length Matrix (GLRLM), Gray Level Co-occurrence Matrix (GLCM), morphological features, and Local Binary Patterns. A four-fold multi-label cross-validation approach was employed on a benchmark dataset to evaluate the model's performance. Quantitative analysis reveals that PAIMC consistently achieves superior Decision Accuracy, F-Score, Specificity, Sensitivity Recall, and Precision metrics compared to existing state-of-the-art models. For instance, PAIMC's Decision Accuracy and Precision outperform the second-best model by a notable margin across all folds. The model also demonstrates a significant improvement in Sensitivity Recall and Specificity, reinforcing its efficacy in the multi-class classification of AD stages. A novel data diversity assessment measure was developed and utilized, further confirming the robustness of the PAIMC model. The results underscore the potential of PAIMC as a highly accurate tool for AD classification in clinical settings.