偏头痛发作间期的注意力、警觉性和执行功能障碍及其预防性治疗的逆转:纵向对照研究

D. Chowdhury, Debabrata Datta, A. Mundra, A. Duggal, Anand Krishnan
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引用次数: 0

摘要

目的:评估偏头痛患者在无头痛(发作间期)期间以及无偏头痛的健康对照组的注意力、警觉性和执行功能,并研究偏头痛预防性治疗对这些认知功能的影响。 研究对象为年龄≥18岁、无药物过量使用史的预防性药物治疗偏头痛患者,并与非偏头痛对照组进行了比较。研究人员通过患者健康问卷-9对偏头痛患者进行了精神合并症筛查,并通过特定量表对筛查结果呈阳性的偏头痛患者进行了进一步评估。埃普沃思嗜睡量表评估了对睡眠质量的主观抱怨。认知功能通过迷你精神状态检查(MMSE)、数字跨度正向和反向(DS-F、DS-B)、线索制作测试(TMT-A 和 B)以及 Stroop 单词(SW)、Stroop 颜色(SC)和 Stroop 干扰(SI)测试进行评估。将治疗结束后 6 个月的认知测试得分与基线得分进行比较。 研究对象包括偏头痛患者和对照组各150人。与对照组相比,偏头痛患者在DS-B(P<0.0001)、TMT-A(P=0.00004)、TMT-B(P<0.0001)、SW(P<0.0001)、SC(P<0.0001)和SI(P=0.0221)方面的表现明显较差。患者与对照组的 MMSE 评分没有差异(P = 0.3224)。与没有合并精神疾病的患者相比,合并精神疾病的偏头痛患者在认知测试得分上没有明显差异。治疗6个月后,所有认知测试得分均有显著改善(P < 0.001)。 与非偏头痛对照组相比,偏头痛患者在发作间期表现出注意力、警觉性和执行功能的缺陷,这些缺陷在成功的预防性治疗后有所改善。精神并发症对认知功能障碍没有显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interictal Dysfunctions of Attention, Vigilance, and Executive Functions in Migraine and Their Reversal by Preventive Treatment: A longitudinal Controlled Study
To assess attention, vigilance, and executive functions in migraine patients during headache-free (interictal) periods and in healthy controls without migraine and to study the impact of migraine preventive treatment on these cognitive functions. Preventive drug-naive migraine patients, aged ≥18 years, without a history of medication overuse were studied and compared to non-migraine controls. Psychiatric comorbidity was screened by Patient Health Questionnaire-9, and those who screened positive were evaluated further by specific scales. The Epworth Sleepiness Scale assessed subjective complaints of sleep quality. Cognitive functions were assessed by Mini-Mental State Examination (MMSE), digit span forward and backward (DS-F, DS-B), trail-making tests (TMT-A and B) and Stroop word (SW), Stroop color (SC), and Stroop interference (SI) tests. Cognitive test scores at the end of 6 months following treatment were compared to baseline scores. One hundred and fifty migraine patients and controls each were studied. Compared to controls, migraine patients performed significantly worse in DS-B (P < 0.0001), TMT-A (P = 0.00004), TMT-B (P < 0.0001), SW (P < 0.0001), SC (P < 0.0001), and SI (P = 0.0221). MMSE scores did not differ between patients and the controls (P = 0.3224). Compared to the patients without psychiatric comorbidity, migraine patients with psychiatric comorbidity showed no significant differences in the cognitive test scores. Significant improvement in all cognitive test scores (P < 0.001) was observed after 6 months of treatment. Migraine patients, compared to non-migraine controls, showed deficits in attention, vigilance, and executive functions during the interictal period, which improved with successful preventive treatment. Psychiatric comorbidities did not have a significant impact on cognitive dysfunctions.
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