{"title":"雾化与注射在急性哮喘门诊治疗中的比较研究","authors":"Christer Janson, Merja Herala, Ingela Sjögren","doi":"10.1016/0007-0971(88)90087-3","DOIUrl":null,"url":null,"abstract":"<div><p>Nebulization treatment of acute asthma with terbutaline and ipratropium bromide, given either separately with a 30-minute interval or combined as single inhalation, was compared with injection treatment with a combination of terbutaline given subcutaneously and theophylline given intravenously.</p><p>Seventy-seven episodes of acute asthma were studied. Nebulization treatment gave the same degree of bronchodilation as the injections, both immediately after treatment [measured as increase in forced expiratory volume in 1 second (FEV<sub>1</sub>) in peak expiratory flow rate (PEFR) and improvement of dyspnoea] and during the following 6 days (measured by PEFR recordings at home).</p><p>The injection treatment caused a moderate increase in heart rate, whereas no circulatory side-effects were noted during nebulization treatment.</p><p>Administration of ipratropium bromide 30 minutes after terbutaline was not more effective than the combination of both substances as a single nebulization.</p></div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 347-353"},"PeriodicalIF":0.0000,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90087-3","citationCount":"14","resultStr":"{\"title\":\"Nebulization versus injection in ambulatory treatment of acute asthma: a comparative study\",\"authors\":\"Christer Janson, Merja Herala, Ingela Sjögren\",\"doi\":\"10.1016/0007-0971(88)90087-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Nebulization treatment of acute asthma with terbutaline and ipratropium bromide, given either separately with a 30-minute interval or combined as single inhalation, was compared with injection treatment with a combination of terbutaline given subcutaneously and theophylline given intravenously.</p><p>Seventy-seven episodes of acute asthma were studied. Nebulization treatment gave the same degree of bronchodilation as the injections, both immediately after treatment [measured as increase in forced expiratory volume in 1 second (FEV<sub>1</sub>) in peak expiratory flow rate (PEFR) and improvement of dyspnoea] and during the following 6 days (measured by PEFR recordings at home).</p><p>The injection treatment caused a moderate increase in heart rate, whereas no circulatory side-effects were noted during nebulization treatment.</p><p>Administration of ipratropium bromide 30 minutes after terbutaline was not more effective than the combination of both substances as a single nebulization.</p></div>\",\"PeriodicalId\":75618,\"journal\":{\"name\":\"British journal of diseases of the chest\",\"volume\":\"82 \",\"pages\":\"Pages 347-353\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0007-0971(88)90087-3\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British journal of diseases of the chest\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0007097188900873\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of diseases of the chest","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0007097188900873","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Nebulization versus injection in ambulatory treatment of acute asthma: a comparative study
Nebulization treatment of acute asthma with terbutaline and ipratropium bromide, given either separately with a 30-minute interval or combined as single inhalation, was compared with injection treatment with a combination of terbutaline given subcutaneously and theophylline given intravenously.
Seventy-seven episodes of acute asthma were studied. Nebulization treatment gave the same degree of bronchodilation as the injections, both immediately after treatment [measured as increase in forced expiratory volume in 1 second (FEV1) in peak expiratory flow rate (PEFR) and improvement of dyspnoea] and during the following 6 days (measured by PEFR recordings at home).
The injection treatment caused a moderate increase in heart rate, whereas no circulatory side-effects were noted during nebulization treatment.
Administration of ipratropium bromide 30 minutes after terbutaline was not more effective than the combination of both substances as a single nebulization.
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