奥马他环素治疗军团菌肺炎的疗效:病例报告

Yao Wang, Shui-Min Yi, Si-Min Huang, Wei Xu, Yi-Wen Wei, Qiang Qu, Jian Qu
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引用次数: 0

摘要

军团菌是引起社区获得性肺炎的主要病原体之一,可导致以重症肺炎为主要特征的军团菌肺炎。这种由嗜肺军团菌引起的疾病可迅速发展为重症肺炎,并常常伴有多个器官的损伤。因此,在临床诊断和治疗方面需要密切关注。奥马他环素是一种新型四环素衍生物,属于氨甲基环素类抗生素,是由米诺环素衍生的半合成化合物。其主要结构特征是氨甲基修饰,这使奥马他环素能够克服细菌的抗药性,并扩大其对细菌的有效范围。临床研究表明,奥马他环素不会在体内代谢,肝肾功能不全的患者无需调整剂量。本文报告了一例使用奥马他环素成功治疗军团菌肺炎的病例,该患者最初对莫西沙星的经验性治疗无效。该患者还出现了电解质紊乱、肝肾功能障碍、谵妄和其他相关精神症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of omadacycline in the treatment of Legionella pneumonia: a case report
Legionella, one of the main pathogens that causes community-acquired pneumonia, can lead to Legionella pneumonia, a condition characterized predominantly by severe pneumonia. This disease, caused by the bacterium Legionella pneumophila, can quickly progress to critical pneumonia and is often associated with damage to multiple organs. As a result, it requires close attention in terms of clinical diagnosis and treatment. Omadacycline, a new type of tetracycline derivative belonging to the aminomethylcycline class of antibiotics, is a semi-synthetic compound derived from minocycline. Its key structural feature, the aminomethyl modification, allows omadacycline to overcome bacterial resistance and broadens its range of effectiveness against bacteria. Clinical studies have demonstrated that omadacycline is not metabolized in the body, and patients with hepatic and renal dysfunction do not need to adjust their dosage. This paper reports a case of successful treatment of Legionella pneumonia with omadacycline in a patient who initially did not respond to empirical treatment with moxifloxacin. The patient also experienced electrolyte disturbance, as well as dysfunction in the liver and kidneys, delirium, and other related psychiatric symptoms.
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