Fomentariol 是一种 Fomes fomentarius 化合物，在真菌材料中具有抗糖尿病作用：体外分析

Nutraceuticals Pub Date : 2024-05-21 DOI:10.3390/nutraceuticals4020017

M. Ravnikar, Borut Štrukelj, Biljana Otašević, Mateja Sirše

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引用次数: 0

摘要

本研究筛选了各种真菌物种，以寻找对碳水化合物代谢至关重要的α-葡萄糖苷酶、α-淀粉酶和DPP-4酶的抑制剂。乙醇提取物的抑制活性优于水提取物，这表明它们具有作为抗糖尿病药物来源的潜力。进一步的分馏结果表明，福美双中的福门塔里醇是α-葡萄糖苷酶和DPP-4的强效抑制剂，对α-葡萄糖苷酶的活性高于阿卡波糖。Fomentariol 能同时抑制葡萄糖代谢中的关键酶，为糖尿病治疗提供了一条新途径。不过，还需要进行全面的临床研究，以评估其对人体的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis

The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha-glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.

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Nutraceuticals

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