从肠道微生物群的角度重新评估痛风的治疗方法

Jean Demarquoy, Oumaima Dehmej
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摘要

痛风是炎症性关节炎中最常见的一种,由尿酸结晶堆积引起,导致剧烈疼痛,尤其是在大脚趾部位。这种情况传统上与尿酸分泌过多或清除减少有关。然而,最近的研究强调了肠道微生物群在尿酸代谢中的重要作用,对尿酸的产生和排出都有影响。这种新的认识表明,保持肠道健康可以为治疗痛风提供创新方法,补充传统的饮食和药物干预措施。它凸显了益生菌或基于微生物组的疗法的潜力,预示着根据个体微生物组进行治疗的未来。这为痛风的治疗提供了一个全新的视角,并强调了微生物群对健康和疾病的广泛影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reassessing Gout Management through the Lens of Gut Microbiota
Gout, recognized as the most common form of inflammatory arthritis, arises from the accumulation of uric acid crystals, leading to intense pain, particularly in the big toe. This condition has traditionally been associated with the overproduction or reduced clearance of uric acid. Recent studies, however, have underscored the significant role of the gut microbiota in uric acid metabolism, impacting both its production and elimination. This emerging understanding suggests that maintaining gut health could offer innovative approaches to treating gout, complementing traditional dietary and pharmacological interventions. It highlights the potential of probiotics or microbiome-based therapies, indicating a future where treatments are tailored to an individual’s microbiome. This offers a fresh perspective on gout management and underscores the broader influence of the microbiota on health and disease.
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