粪便微生物群移植治疗肝性脑病:透视

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
A. Samanta, Moinak Sen Sarma
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引用次数: 0

摘要

由于肝性脑病(HE)的发病机制复杂,其治疗仍然是一项挑战。近来,肠道微生物群因其在各种胃肠道和肝脏疾病发病机制中的作用及其潜在的治疗用途而备受关注。新的证据表明,肠道微生物群在大脑稳态中发挥着重要作用。许多临床和实验研究都记录了 HE 患者肠道微生物群的改变。对高血压患者肠道菌群失调的研究为益生菌、益生元和最新的粪便微生物群移植(FMT)开辟了新的治疗途径。最近的研究表明,FMT 是安全的,而且可以有效改善晚期肝病患者的预后。然而,如何使用适当的剂量、疗程和给药途径才能达到最佳治疗效果,目前仍是一个悬而未决的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fecal microbiota transplantation in the treatment of hepatic encephalopathy: A perspective
Due to its complex pathogenesis, treatment of hepatic encephalopathy (HE) continues to be a therapeutic challenge. Of late, gut microbiome has garnered much attention for its role in the pathogenesis of various gastrointestinal and liver diseases and its potential therapeutic use. New evidence suggests that gut microbiota plays a significant role in cerebral homeostasis. Alteration in the gut microbiota has been documented in patients with HE in a number of clinical and experimental studies. Research on gut dysbiosis in patients with HE has opened newer therapeutic avenues in the form of probiotics, prebiotics and the latest fecal microbiota transplantation (FMT). Recent studies have shown that FMT is safe and could be effective in improving outcomes in advanced liver disease patients presenting with HE. However, questions over the appropriate dose, duration and route of administration for best treatment outcome remains unsettled.
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来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
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