合并肝细胞性胆管癌:临床病理学最新进展

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
M. Vij, Fadl H Veerankutty, A. Rammohan, Mohamed Rela
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引用次数: 0

摘要

肝细胞胆管癌(cHCC-CCA)是一种罕见的原发性肝癌,预后极差。对于内科医生、放射科医生、外科医生、病理学家和肿瘤学家来说,这种疾病的诊断和治疗都是一项挑战。最近,人们开始探索生物标志物的诊断和预后价值,如免疫组化表达的 nestin(一种祖细胞标志物)。随着对 cHCC-CCA 的生物学和临床过程有了更好的了解,人们正在尝试采用免疫检查点抑制剂等新的治疗方式来改善这种罕见疾病患者的生存率。在这篇综述中,我们将介绍 cHCC-CCA 在病理学、诊断方法和治疗方面的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Combined hepatocellular cholangiocarcinoma: A clinicopathological update
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer associated with an appalling prognosis. The diagnosis and management of this entity have been challenging to physicians, radiologists, surgeons, pathologists, and oncologists alike. The diagnostic and prognostic value of biomarkers such as the immunohistochemical expression of nestin, a progenitor cell marker, have been explored recently. With a better understanding of biology and the clinical course of cHCC-CCA, newer treatment modalities like immune checkpoint inhibitors are being tried to improve the survival of patients with this rare disease. In this review, we give an account of the recent developments in the pathology, diagnostic approach, and management of cHCC-CCA.
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来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
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