Guoshuai Li, Yifei Yan, Jinghong Tang, Qingxue Ma, Jun Huang, Xiaohua Xu* and Zhong Jin*,
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Regiodivergent Remote C–H Functionalization by Tuning Template Geometry
For transition-metal-catalyzed C–H functionalization, precise differentiation between remote adjacent C(sp2)–H bonds remains a long-standing challenge. Here, the template structure–directivity relationship on remote C–H functionalization of arenes was experimentally and computationally studied. By using geometry-tunable templates, Pd-catalyzed remote meta- and para-C–H activation of benzoic acids was achieved with high site selectivity.
期刊介绍:
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.