rRNA 在维持基因组稳定性方面的作用。

IF 3 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2024-05-12 DOI:10.1016/j.dnarep.2024.103692

Peng Li , Xiaochun Yu

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引用次数: 0

摘要

过去几十年来，基因筛选和蛋白质亲和纯化等无偏见的方法揭示了许多参与 DNA 双链断裂（DSB）修复和维持基因组稳定性的蛋白质。然而，尽管我们对这些蛋白因子有所了解，但在DSB修复过程中调控关键细胞事件的潜在分子机制仍然难以捉摸。最近的证据揭示了非蛋白因子（如 RNA）在 DSB 修复的几个关键步骤中的作用。在这篇综述中，我们全面总结了这些最新发现，强调了核糖体 RNA（rRNA）作为 DNA 损伤反应、减数分裂和有丝分裂的关键介质的重要性。此外，我们还讨论了 rRNA 影响基因组完整性的潜在机制。

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The role of rRNA in maintaining genome stability

Over the past few decades, unbiased approaches such as genetic screening and protein affinity purification have unveiled numerous proteins involved in DNA double-strand break (DSB) repair and maintaining genome stability. However, despite our knowledge of these protein factors, the underlying molecular mechanisms governing key cellular events during DSB repair remain elusive. Recent evidence has shed light on the role of non-protein factors, such as RNA, in several pivotal steps of DSB repair. In this review, we provide a comprehensive summary of these recent findings, highlighting the significance of ribosomal RNA (rRNA) as a critical mediator of DNA damage response, meiosis, and mitosis. Moreover, we discuss potential mechanisms through which rRNA may influence genome integrity.

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.