NAFLD 发病机制及与心血管疾病的临床关联

Health Sciences Pub Date : 2024-05-01 DOI:10.35988/sm-hs.2024.129

Julija Valaitienė

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引用次数: 0

摘要

非酒精性脂肪肝（NAFLD）是一个不断扩大的预防和治疗问题。非酒精性脂肪肝的核心病理过程包括病理性脂质蓄积导致的胰岛素抵抗、氧化应激、线粒体功能障碍、炎症和内质网应激。非酒精性脂肪肝与重大心血管事件风险的增加密切相关。本文献综述旨在概述非酒精性脂肪肝的病理生理机制，并证明非酒精性脂肪肝与心血管并发症风险增加之间的联系。

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NAFLD PATHOGENESIS AND CLINICAL ASSOCIATIONS WITH CARDIOVASCULAR DISEASES

Non-alcoholic fatty liver disease (NAFLD) is an expanding issue in prevention and treatment. The central pathological processes of NAFLD comprise pathological lipid accumulation resulting in insulin resistance, oxidative stress, mitochondrial dysfunction, inflammation, and endoplasmic reticulum stress. NAFLD is firmly associated with a raised risk of major cardiovascular events. This literature review seeks to overview the pathophysiological mechanisms of NAFLD and provide proof of a connection between NAFLD and an augmented risk of cardiovascular complications.

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Health Sciences

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