{"title":"阑尾病变的组织形态谱","authors":"Mitali Priya Netam, Rachana S. Binayke","doi":"10.36106/ijsr/9802942","DOIUrl":null,"url":null,"abstract":"Introduction: The appendix, which is a vestigial organ in humans, is attached to caecum. The disease appendicitis is one of the commonest causes\nof acute abdomen. It is also the commonest reason of the emergency surgery that can lead to signicant morbidity and mortality. Usually when\n(1) appendectomy is done early, it relieves all the symptoms. The misdiagnosis related to the disease often leads to removal of uninamed appendix.\nThe précised aetiology of appendicitis is uncertain, although the most common hypothesis is the obstruction of appendiceal lumen with secondary\ninfection. The luminal and intraluminal pressure and due to the constant pressure, the thrombosis of appendicular vasculature and venous\nobstruction occurs resulting in ischemia. The bacteria enter the damaged mucosa and the pus forms inside the appendix eventually causing the\n(2) infarction and perforation. Aim: We aimed at determining the spectrum, histopathology and prevalence of lesions in appendix in our tertiary care\nhospital. Material And Methods: This is a retrospective study conducted in the department of pathology in tertiary care hospital, Mumbai over a\nperiod of 18 months. 300 specimens of appendicular lesions received during the study period. The specimens were xed in 10% formalin and\nstained with Haematoxylin and Eosin stain. The lesions were classied based on their histomorphological ndings. Results: This study included\ntotal of 300 specimens of resected appendix. In the present study, the total sample number received during study period was 7840, Out of which\ntotal number of appendicectomy specimens were 300 (3.82%). present study, the age group from the paediatric to geriatric age group were\nconsidered. Majority of patients 99(33%) belong to 21-30 years age group. During the study period, a total number of 300 patients had\nappendectomy out of which, the number of males was higher than females, with 60% of the cases being male, 40 % being female. In the present\nstudy, the non-neoplastic lesions were found in majority. Out of 300 cases, he non- neoplastic lesions accounted for 295 cases (98.4%) and\nneoplastic lesions contributes 5 cases (1.66%). Conclusions: According to the current study, men are slightly more likely than women to develop\nappendicitis with predominancy in second and third decades of life. In all cases of acute appendicitis, a histopathological examination of the\nappendix should be done since it provides crucial clinical information in addition to the operational results. The importance of histological\ninvestigation of every resected appendix is demonstrated by uncommon discoveries such as low grade appendiceal mucinous neoplasia and\nadenocarcinoma in clinically suspected acute appendicitis, the presence of which alters the subsequent therapy. Thus, we draw the conclusion that\nthe histological analysis is still the best method for identifying appendiceal lesions.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"24 8","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"HISTOMORPHOLOGICAL SPECTRUM OF APPENDICULAR LESIONS\",\"authors\":\"Mitali Priya Netam, Rachana S. Binayke\",\"doi\":\"10.36106/ijsr/9802942\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: The appendix, which is a vestigial organ in humans, is attached to caecum. The disease appendicitis is one of the commonest causes\\nof acute abdomen. It is also the commonest reason of the emergency surgery that can lead to signicant morbidity and mortality. Usually when\\n(1) appendectomy is done early, it relieves all the symptoms. The misdiagnosis related to the disease often leads to removal of uninamed appendix.\\nThe précised aetiology of appendicitis is uncertain, although the most common hypothesis is the obstruction of appendiceal lumen with secondary\\ninfection. The luminal and intraluminal pressure and due to the constant pressure, the thrombosis of appendicular vasculature and venous\\nobstruction occurs resulting in ischemia. The bacteria enter the damaged mucosa and the pus forms inside the appendix eventually causing the\\n(2) infarction and perforation. Aim: We aimed at determining the spectrum, histopathology and prevalence of lesions in appendix in our tertiary care\\nhospital. Material And Methods: This is a retrospective study conducted in the department of pathology in tertiary care hospital, Mumbai over a\\nperiod of 18 months. 300 specimens of appendicular lesions received during the study period. The specimens were xed in 10% formalin and\\nstained with Haematoxylin and Eosin stain. The lesions were classied based on their histomorphological ndings. Results: This study included\\ntotal of 300 specimens of resected appendix. In the present study, the total sample number received during study period was 7840, Out of which\\ntotal number of appendicectomy specimens were 300 (3.82%). present study, the age group from the paediatric to geriatric age group were\\nconsidered. Majority of patients 99(33%) belong to 21-30 years age group. During the study period, a total number of 300 patients had\\nappendectomy out of which, the number of males was higher than females, with 60% of the cases being male, 40 % being female. In the present\\nstudy, the non-neoplastic lesions were found in majority. Out of 300 cases, he non- neoplastic lesions accounted for 295 cases (98.4%) and\\nneoplastic lesions contributes 5 cases (1.66%). Conclusions: According to the current study, men are slightly more likely than women to develop\\nappendicitis with predominancy in second and third decades of life. In all cases of acute appendicitis, a histopathological examination of the\\nappendix should be done since it provides crucial clinical information in addition to the operational results. The importance of histological\\ninvestigation of every resected appendix is demonstrated by uncommon discoveries such as low grade appendiceal mucinous neoplasia and\\nadenocarcinoma in clinically suspected acute appendicitis, the presence of which alters the subsequent therapy. Thus, we draw the conclusion that\\nthe histological analysis is still the best method for identifying appendiceal lesions.\",\"PeriodicalId\":14358,\"journal\":{\"name\":\"International journal of scientific research\",\"volume\":\"24 8\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of scientific research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36106/ijsr/9802942\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of scientific research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36106/ijsr/9802942","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
HISTOMORPHOLOGICAL SPECTRUM OF APPENDICULAR LESIONS
Introduction: The appendix, which is a vestigial organ in humans, is attached to caecum. The disease appendicitis is one of the commonest causes
of acute abdomen. It is also the commonest reason of the emergency surgery that can lead to signicant morbidity and mortality. Usually when
(1) appendectomy is done early, it relieves all the symptoms. The misdiagnosis related to the disease often leads to removal of uninamed appendix.
The précised aetiology of appendicitis is uncertain, although the most common hypothesis is the obstruction of appendiceal lumen with secondary
infection. The luminal and intraluminal pressure and due to the constant pressure, the thrombosis of appendicular vasculature and venous
obstruction occurs resulting in ischemia. The bacteria enter the damaged mucosa and the pus forms inside the appendix eventually causing the
(2) infarction and perforation. Aim: We aimed at determining the spectrum, histopathology and prevalence of lesions in appendix in our tertiary care
hospital. Material And Methods: This is a retrospective study conducted in the department of pathology in tertiary care hospital, Mumbai over a
period of 18 months. 300 specimens of appendicular lesions received during the study period. The specimens were xed in 10% formalin and
stained with Haematoxylin and Eosin stain. The lesions were classied based on their histomorphological ndings. Results: This study included
total of 300 specimens of resected appendix. In the present study, the total sample number received during study period was 7840, Out of which
total number of appendicectomy specimens were 300 (3.82%). present study, the age group from the paediatric to geriatric age group were
considered. Majority of patients 99(33%) belong to 21-30 years age group. During the study period, a total number of 300 patients had
appendectomy out of which, the number of males was higher than females, with 60% of the cases being male, 40 % being female. In the present
study, the non-neoplastic lesions were found in majority. Out of 300 cases, he non- neoplastic lesions accounted for 295 cases (98.4%) and
neoplastic lesions contributes 5 cases (1.66%). Conclusions: According to the current study, men are slightly more likely than women to develop
appendicitis with predominancy in second and third decades of life. In all cases of acute appendicitis, a histopathological examination of the
appendix should be done since it provides crucial clinical information in addition to the operational results. The importance of histological
investigation of every resected appendix is demonstrated by uncommon discoveries such as low grade appendiceal mucinous neoplasia and
adenocarcinoma in clinically suspected acute appendicitis, the presence of which alters the subsequent therapy. Thus, we draw the conclusion that
the histological analysis is still the best method for identifying appendiceal lesions.