Sally M. Ismael MBBCH , Dina S. Atia MD , Salwa A. Atlam MD , Abeer A. Eltoukhy MD , Amira Hamed Darwish MD
{"title":"脑瘫儿童的幽门螺杆菌感染:横断面研究","authors":"Sally M. Ismael MBBCH , Dina S. Atia MD , Salwa A. Atlam MD , Abeer A. Eltoukhy MD , Amira Hamed Darwish MD","doi":"10.1016/j.pediatrneurol.2024.04.024","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Children with cerebral palsy (CP) frequently have associated disorders and complications, including gastrointestinal problems. <em>Helicobacter pylori</em> is a common infection worldwide, frequently associated with gastrointestinal manifestations.</p></div><div><h3>Methods</h3><p>To estimate the prevalence of <em>H</em>. <em>pylori</em> infection in children with CP<em>,</em> a cross-sectional study over an eight-month period was performed in the pediatric neurology outpatient clinic of Tanta University Hospital. The study included 100 patients with CP aged two to 17 years. All patients were tested for <em>H. pylori</em> antigen in stool by enzyme-linked immunosorbent assay.</p></div><div><h3>Results</h3><p>The mean age of studied children with CP was 7.03 ± 4.1 years; there were 57 males and 43 females. Spastic quadriplegic CP was the most common type of CP (34%). Forty-five children with CP were positive for <em>H. pylori</em> antigen in stool. Intellectual disability (ID), low sociodemographic scoring system, semisolid diet, and Eating and Drinking Ability Classification System (EDACS) levels 4 and 5 were significant predictors of <em>H. pylori</em> infection (odds ratio of 1.86, 2.63, 12, and 1.77, respectively, <em>P</em> < 0.05). Vomiting, abdominal pain, and gastrointestinal tract bleeding were significantly more frequent in <em>H. pylori</em>-infected children with CP than noninfected children with CP (<em>P</em> value < 0.05)</p></div><div><h3>Conclusion</h3><p><em>H. pylori</em> is a relatively common infection among children with CP. The main risk factors for <em>H. pylori</em> infection were low socioeconomic level, ID, semisolid diet, and EDACS levels 4 and 5.</p></div>","PeriodicalId":19956,"journal":{"name":"Pediatric neurology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Helicobacter pylori Infection in Children With Cerebral Palsy: A Cross-Sectional Study\",\"authors\":\"Sally M. Ismael MBBCH , Dina S. Atia MD , Salwa A. Atlam MD , Abeer A. Eltoukhy MD , Amira Hamed Darwish MD\",\"doi\":\"10.1016/j.pediatrneurol.2024.04.024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Children with cerebral palsy (CP) frequently have associated disorders and complications, including gastrointestinal problems. <em>Helicobacter pylori</em> is a common infection worldwide, frequently associated with gastrointestinal manifestations.</p></div><div><h3>Methods</h3><p>To estimate the prevalence of <em>H</em>. <em>pylori</em> infection in children with CP<em>,</em> a cross-sectional study over an eight-month period was performed in the pediatric neurology outpatient clinic of Tanta University Hospital. The study included 100 patients with CP aged two to 17 years. All patients were tested for <em>H. pylori</em> antigen in stool by enzyme-linked immunosorbent assay.</p></div><div><h3>Results</h3><p>The mean age of studied children with CP was 7.03 ± 4.1 years; there were 57 males and 43 females. Spastic quadriplegic CP was the most common type of CP (34%). Forty-five children with CP were positive for <em>H. pylori</em> antigen in stool. Intellectual disability (ID), low sociodemographic scoring system, semisolid diet, and Eating and Drinking Ability Classification System (EDACS) levels 4 and 5 were significant predictors of <em>H. pylori</em> infection (odds ratio of 1.86, 2.63, 12, and 1.77, respectively, <em>P</em> < 0.05). Vomiting, abdominal pain, and gastrointestinal tract bleeding were significantly more frequent in <em>H. pylori</em>-infected children with CP than noninfected children with CP (<em>P</em> value < 0.05)</p></div><div><h3>Conclusion</h3><p><em>H. pylori</em> is a relatively common infection among children with CP. The main risk factors for <em>H. pylori</em> infection were low socioeconomic level, ID, semisolid diet, and EDACS levels 4 and 5.</p></div>\",\"PeriodicalId\":19956,\"journal\":{\"name\":\"Pediatric neurology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-05-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric neurology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S088789942400153X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric neurology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S088789942400153X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Helicobacter pylori Infection in Children With Cerebral Palsy: A Cross-Sectional Study
Background
Children with cerebral palsy (CP) frequently have associated disorders and complications, including gastrointestinal problems. Helicobacter pylori is a common infection worldwide, frequently associated with gastrointestinal manifestations.
Methods
To estimate the prevalence of H. pylori infection in children with CP, a cross-sectional study over an eight-month period was performed in the pediatric neurology outpatient clinic of Tanta University Hospital. The study included 100 patients with CP aged two to 17 years. All patients were tested for H. pylori antigen in stool by enzyme-linked immunosorbent assay.
Results
The mean age of studied children with CP was 7.03 ± 4.1 years; there were 57 males and 43 females. Spastic quadriplegic CP was the most common type of CP (34%). Forty-five children with CP were positive for H. pylori antigen in stool. Intellectual disability (ID), low sociodemographic scoring system, semisolid diet, and Eating and Drinking Ability Classification System (EDACS) levels 4 and 5 were significant predictors of H. pylori infection (odds ratio of 1.86, 2.63, 12, and 1.77, respectively, P < 0.05). Vomiting, abdominal pain, and gastrointestinal tract bleeding were significantly more frequent in H. pylori-infected children with CP than noninfected children with CP (P value < 0.05)
Conclusion
H. pylori is a relatively common infection among children with CP. The main risk factors for H. pylori infection were low socioeconomic level, ID, semisolid diet, and EDACS levels 4 and 5.
期刊介绍:
Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system.
Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.