A 型肉毒毒素治疗中重度面部皱纹的安全性和有效性

Adarsh Shetty
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引用次数: 0

摘要

背景与目的:A 型肉毒杆菌毒素是参与面部年轻化治疗的最有效血清型。在真实世界的临床实践中,对 A 型肉毒杆菌毒素治疗中重度面部皱纹的安全性和有效性进行了评估。材料和方法:研究对象包括患有中度至重度面部皱纹的男性和女性。根据具体情况,对单个或多个面部区域进行治疗。首要目标是评估所用配方的安全性和耐受性。次要目标是根据研究者和受试者评估的莫迪ed Global Aesthetic ImprovementScale (GAIS),评估治疗的有效性。研究涉及 100 名参与者,其中大部分为女性(64%),平均年龄(±S.D.)为 40.7±6.2 岁:40.7±6.2岁。其中 8 人共报告了 10 例不良事件(AEs),如头痛(3%)和前额沉重(2%),但没有人报告严重不良事件(SAEs)。研究显示,经研究者和受试者评估,GAIS(全球美学改善量表)的 1、2 和 3 区均有显著改善。此外,报告 "我看起来更年轻了 "的受试者比例从第 1 次的 3% 显著c,增至第 4 次的 70.7%。结论:A 型肉毒杆菌毒素似乎是一种耐受性良好且有效的治疗选择,可改善面部外观并提高生活质量。与治疗相关的不良事件(TEAEs)和严重不良事件(SAEs)极少,甚至没有。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SAFETY AND EFFICACY OF BOTULINUM TOXIN TYPE A IN THE MANAGEMENT OF MODERATE TO SEVERE FACIAL WRINKLES
Background & Aim: Botulinum Toxin A is the most potent serotype, involved in the management of facial rejuvenation. The safety and effectiveness of Botulinum Toxin Type-A was evaluated for managing moderate to severe facial wrinkles in real-world clinical practice. Materials and Methods: Male and female subjects with moderate to severe facial wrinkles were included. Treatment was administered to single or multiple facial zones, depending on the case. The primary objective was to assess the safety and tolerability of the formulation used. The secondary objectives were to assess the effectiveness of the treatment based on the Investigator and subject-assessed Modied Global Aesthetic Improvement Scale (GAIS). The study involved 100 participants, mostly females (64%), with a mean (±S.D.) age of Results: 40.7±6.2 years. Eight of them reported a total of 10 adverse events (AEs), such as headache (3%) and heaviness of forehead (2%), but none reported serious adverse events (SAEs). The study revealed statistically signicant improvements, as assessed by the investigator and the subjects, in zones 1, 2, and 3 of the GAIS (Global Aesthetic Improvement Scale). Moreover, the percentage of subjects reporting "I look younger" increased from 3% in visit 1 to 70.7% in visit 4, signicantly. Botulinum toxin A appears to be well-tolerated and effective treatment opti Conclusion: on that enhances facial appearance and quality of life. It was associated with very few to no treatment-associated adverse events (TEAEs) and serious adverse events (SAEs).
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