评估东奈综合医院 39 名甲状腺癌患者体内 I-131 的有效半衰期

Tan Duoc Nguyen, Ha Phuong Do, Pham Ngoc Trinh Tran
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引用次数: 0

摘要

通过放射性碘治疗杀死甲状腺癌患者术后残留的细胞是目前广泛采用的治疗方法。尽管治疗效果显著,但残留在患者体内的 I-131 也会对护理人员和密切接触者造成辐射风险。本研究评估了在东奈综合医院接受甲状腺癌治疗的 39 名患者体内 I-131 的有效半衰期()。在用药后 0.5、2.0、4.0、6.0、24.0 小时和 7 天,使用离患者 1.0 米远的 GAL20-C 测量仪(ELSE SOLUTIONS)测量患者体内的放射性活度。用最小二乘法将测量数据与时间相关的单指数函数进行拟合,以计算出有效半衰期。结果函数具有良好的判定系数 R2 ~ 1,Te 为 7.89 +- 1.55 小时(高活性组)和 5.83+-1.76 小时(低活性组)。事实证明,这两组患者的有效半衰期是不同的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing effective half-life of I-131 in 39 thyroid cancer patients at Dong Nai General Hospital
Radioiodine therapy to kill the residual cells after surgery in thyroid cancer patients is a widespread treatment method nowadays. Despite the therapeutic benefits, the amount of I-131 that remains in the patient's body also causes radiation risks to caregivers and persons in close contact. This study assesses the effective half-life () of I-131 in 39 patients underwent thyroid cancer treatment at Dong Nai General Hospital. Radioactive activity on the patient's body was measured by survey meter GAL20-C (ELSE SOLUTIONS), placed 1.0 meters away from the patient, at 0.5; 2.0; 4.0; 6.0; 24.0 hours; and 7 days after administration. The measurement data was fitted by a mono-exponential function respecting time by the least squares method to figure out the effective half-life. The result function has a good coefficient of determination, R2 ~ 1, Te was 7.89 +- 1.55 h (high-activity group), and 5.83+-1.76 h  (low-activity group). The effective half-life was proved to be different between these two groups of patients.
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