A. I. Khavkin, A. V. Nalyotov, D. I. Masyuta, R. Makhmutov
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引用次数: 0
摘要
如今,炎症性肠病的发病机制仍不清楚。遗传倾向、免疫调节功能受损、肠道微生物群组成紊乱、暴露于环境因素等因素与肠道粘膜炎症的发生和上皮穿透性增加有关,这些因素决定了疾病的发生和发展。科学文献中有一种理论认为,缺乏维生素 D(以及其他环境因素)会增加患炎症性肠病的风险。然而,关于维生素 D 在胃肠道疾病发病中的作用的研究仍然很少。本文介绍了目前有关维生素 D 在炎症性肠病发病机制中对肠道粘膜屏障功能、免疫系统和肠道微生物群的影响的数据。
Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review
The pathogenesis of inflammatory bowel diseases still remains unclear nowadays. Genetic disposition, impaired immune regulation, disturbance in intestinal microbiota composition, exposure to environmental factors are associated with the development of inflammation in intestinal mucosa and increased epithelial penetrance that define disease's development and progression. There is a theory in scientific literature that vitamin D deficiency (among other environmental factors) increases the risk of inflammatory bowel disease. However, the role of vitamin D in the development of gastrointestinal tract diseases remains poorly studied. This article presents current data on the vitamin D effect on the intestinal mucosa barrier function, on the immune system and on the intestinal microbiota in the context of inflammatory bowel diseases pathogenesis.