Farah W. Al-Humadi, Hiba Waleed Qassim, Ali Majeed Hameed, Ali Jihad Hemid Al-Athari, Bushra Jaber Umran, Rafal J. Al-Saigh
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引用次数: 0
摘要
宫内节育器(IUS)是一种避孕工具,用于控制妇女的生育率和长期避孕。本研究旨在评估铜质和左炔诺孕酮释放型宫内节育器对妇女健康的影响。这是一项描述性横断面研究,从2016年3月至7月在伊拉克希拉门诊就诊的75名妇女中随机抽取(50名妇女使用铜释放型IUS,其余25名妇女使用左炔诺孕酮释放型IUS)。所有妇女的年龄都在 18 至 46 岁之间,使用 IUS 至少三个月。我们测量了血清脑磷脂(SCerP)、血红蛋白、维生素 D(VD)、白细胞介素-6(IL-6)和γ干扰素(IFN-γ)的水平。结果显示,铜释放 IUS 组的血红蛋白和维生素 D 水平较低,SCerP 和促炎细胞因子水平较高。而左炔诺孕酮释放 IUS 组在上述指标上没有明显变化。我们可以得出结论,与铜释放 IUS 相比,左炔诺孕酮释放 IUS 没有任何不良影响,至少在我们的研究考察的参数方面是如此。
Comparative assessment of the effects of two intrauterine systems for long-term contraception on some haematological, biochemical, and immunological markers
An intrauterine system (IUS) is a type of contraception tool that is used in order to control fertility and prevent concep¬tion in women for a long period. The aim of this study was to assess the influence of copper- versus levonorgestrel-releasing IUSs on women’s health. This is a descriptive cross-sectional study of 75 women that were randomly se¬lected (50 women that used a copper-releasing IUS and the remaining 25 that used a levonorgestrel-releasing IUS) amongst those attending out patient’s clinics at Hillah, Iraq, from March to July 2016. All women were between 18 to 46 years of age, and have had an IUS for at least three months. The measurement of serum ceruloplasmin (SCerP), haemoglobin, vitamin D (VD), interleukin-6 (IL-6), and interferon-gamma (IFN-γ) levels was undertaken. Our results revealed that the copper-releasing IUS group has low haemoglobin and VD levels, along with high levels of SCerP and proinflammatory cytokines. One the other hand, the levonorgestrel-releasing IUS group displayed no significant changes on the above markers. We can conclude that the levonorgestrel-releasing IUS is free of any adverse effect when compared to a copper-releasing IUS, at least with regard to the parameters examined by our study.