微乳剂作为治疗眼部真菌感染的新型给药方式

Neha Mandle
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引用次数: 0

摘要

角膜、眼眶和其他眼部组织可能会受到真菌感染。眼部真菌病通常被称为眼部真菌感染,是导致发病和失明的重要原因。针对真菌感染,一种全新的唑类衍生物已获得授权。未来,新的免疫学技术也将有助于提高患者的治疗效果。眼部疾病的治疗在使用传统给药方法(如溶液)将药物送入眼部方面存在很大障碍。主要障碍是血液与眼睛之间、泪液与眼睛之间以及泪液分泌导致药物从眼睛表面流失。为了提高眼部局部用药的生物利用度,延长药物在眼部的停留时间,人们开发了多种眼部给药载体。微乳液是利用相位滴定法制成的。由于微乳剂具有亲水和亲油的双重特性,所含药物可被动扩散,并在不同的亲油-亲水眼屏障中显著分区。本摘要将详细介绍用于治疗眼部真菌感染的微乳剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microemulsion as Novel Drug Delivery for Fungal Eye Infection
The cornea, orbit, and other ocular tissues may get infected by fungi. Ophthalmic mycoses, often known as ocular fungal infections, are a significant cause of morbidity and blindness. For fungus infections, a brand-new azole derivative has been authorized. New immunological techniques would also be beneficial in the future for enhancing patient outcomes. Treatment of ocular illnesses presents a significant barrier in terms of getting medications into the eyes using traditional drug delivery methods, such as solutions. The main barriers are those between blood and the eyes, between lachrymal fluid and the eyes, and between medication losses from the ocular surface brought on by lachrymal fluid secretion. To increase the bioavailability and lengthen the residence duration of medications administered topically to the eye, a variety of ocular drug delivery carriers have been developed. The microemulsion is created using the PHASE TITRATION METHOD. Due to the dual hydrophilic and lipophilic properties of microemulsions, the loaded medications can diffuse passively and become significantly partitioned in the varying lipophilic-hydrophilic ocular barrier. This abstract will provide details on the microemulsions used to treat fungal infections of the eyes.
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