用不同浓度的咖啡酸苯乙酯处理牙本质基质的稳定性

Aline Honorato Damázio, R. Basting, Enrico Coser Bridi, F. França, Flávia Lucisano Botelho do Amaral, C. Turssi, W. F. Vieira Junior, R. Basting
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引用次数: 0

摘要

目的:本研究旨在探讨不同浓度的咖啡酸苯乙酯(CAPE)乙醇溶液预处理对牙本质胶原基质的影响,特别是对其生物改性潜力的影响。通过评估弹性模量和质量变化来评估其生物改性潜力。方法制备 70 个牙本质胶原基质(脱矿棒),分别用浓度为 0.05%、0.1%、0.5% 或 2.5% 的 CAPE 乙醇溶液或对照处理溶液(蒸馏水或乙醇)处理一小时。对牙本质基质进行弹性模量和质量评估,评估时间分别为治疗前(基线)、治疗后立即(立即)以及在模拟体液(SBF)中存放 1 个月和 3 个月。结果:根据时间重复测量的广义线性模型显示,在弹性模量方面,组间(P=0.7530)或不同时间点间(P=0.4780)无明显差异。在质量变化方面,在 1 个月和当前时间之间没有观察到差异(p=0.0935)。然而,在 3 个月时,0.1% CAPE 组与水组相比较,质量损失较少(p=0.0134)。结论本研究得出结论,乙醇溶液中不同浓度的 CAPE 不会影响牙本质的弹性模量,这表明 CAPE 在这方面缺乏生物改性潜力。不过,研究发现 0.1% CAPE 对不同评估时间间隔内的质量变化有积极影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stability of dentin matrix treated with caffeic acid phenethyl ester at different concentrations
Aim: The aim of this study was to investigate the impact of pretreatment with ethanolic solutions of caffeic acid phenethyl ester (CAPE) at varying concentrations on the dentin collagen matrix, specifically focusing on its biomodification potential. This was assessed through evaluations of the modulus of elasticity and changes in mass. Methods: Seventy dentin collagen matrices (demineralized sticks) were prepared to receive treatments with ethanolic solutions of CAPE at concentrations of 0.05%, 0.1%, 0.5%, or 2.5%, or with control treatment solutions (distilled water or ethanol) for one hour. The dentin matrices were evaluated for modulus of elasticity and mass before (baseline), immediately after treatment (immediately), and after storage in Simulated Body Fluid (SBF) for time intervals of 1 and 3 months. Results: Generalized linear models for repeated measures over time indicated no significant differences between groups (p=0.7530) or between different time points (p=0.4780) in terms of the modulus of elasticity. Regarding mass variation, no differences were observed in the time interval between 1 month and the immediate time (p=0.0935). However, at the 3-month mark compared to the immediate time, the 0.1% CAPE group exhibited less mass loss compared to the water group (p=0.0134). Conclusion: This study concludes that various concentrations of CAPE in an ethanolic solution did not affect the modulus of elasticity of dentin, suggesting that CAPE lacks biomodifying potential in this context. However, it was observed that 0.1% CAPE positively influenced the variation in mass over different evaluation time intervals.
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