Archana B, Sri Chaya Reddy Konda, Amulya Shreshta Gadapati, Sadiq Abubakar
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引用次数: 0
摘要
本项目旨在配制和评估以益康唑为基础的透皮贴剂。目前,市场上有售益康唑片剂。这些剂型无法获得患者的配合。因此,由于透皮给药系统使用简单,且能提高患者的依从性,因此作为创新的给药方法,透皮给药系统已开始获得越来越多的关注。本研究旨在使用 HPMC K 15M、HPMC K 100M 和 HPMC K 200M 等聚合物来制作和评估益康唑透皮贴片。采用溶剂浇注技术制作益康唑透皮贴剂。为了确定制剂的大致药物含量,采用了适当的体外技术来研究药物释放模式。长期延缓药物释放。开发一种剂型,防止患者依从性,减少服药次数,以达到最佳药物利用率。Tween 80 增塑剂的浓度对贴片的形成和分离特性至关重要。为了在保质期内用作增塑剂和溶解性增强剂,选择了吐温 80。配方 F-5 已针对所需的质量进行了优化,是一批有效的配方。
Formulate and evaluate transdermal patches using Econazole
The current project aims to formulate and evaluate econazole-based transdermal patches. At present, the market offers econazole tablets for purchase. These dose formulations do not elicit cooperation from patients. Therefore, because transdermal drug administration systems are simple to use and improve patient compliance, they have begun to gain momentum as innovative drug delivery methods. The research aims to use polymers like HPMC K 15M, HPMC K 100M, and HPMC K200M to build and evaluate econazole transdermal patches. The solvent casting technique for making econazole transdermal patches. To determine the formulation's approximate drug content, an appropriate in vitro technique is employed to investigate the drug release pattern. To delay the drug's release over a long period. To develop a dose form that prevents patient compliance and reduces dosage frequency for optimal drug utilization. Tween 80 plasticizer concentration was essential for patch creation and separation characteristics. For use as a plasticizer and solubility enhancer during the shelf life term, Tween 80 is chosen. The formulation F-5 was optimized for the desired qualities and was an effective batch.