贫血儿科患者的血液学特征和明泽尔指数

Aditya Aggarwal, Amit Kumar Modi, R. K, Avinash Kumar Jha
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摘要

研究目的本研究旨在分析贫血儿童的临床和血液学特征,并确定所有贫血病例的门采尔指数:这是一项横断面观察研究,在一所三级护理医学院的儿科系进行。研究共纳入了 80 名经临床检查确诊为贫血的儿科患者。所有病例均记录了年龄和性别等人口统计学细节。在了解病史的同时,还进行了临床检查。同时还记录了主诉。所有病例均进行了全血细胞计数和外周血涂片检查。根据全血细胞计数报告确定门采尔指数:在研究的 80 例病例中,男孩 57 例(71.25%),女孩 23 例(28.75%)。男孩的平均年龄为(9.12±3.14)岁,女孩略高,为(10.24±3.46)岁。乏力(73.75%)、面色苍白(71.25%)和厌食(56.25%)是常见的主诉。约 55% 患有轻度贫血,22.5% 患有中度贫血,22.5% 患有重度贫血。研究发现,病例的平均血红蛋白浓度为 8.42±3.98 g/dL。最常见的血型是正常血细胞正常色素血型,占病例总数的 60%。Mentzer 指数最低为 10.83,最高为 27.76,平均值为(17.40±2.92)。值得注意的是,绝大多数患者(97.5%)的门特泽指数大于 13,这表明缺铁的发病率很高。相反,只有 2.5% 的患者的门策氏指数在 13 或以下,这表明需要通过血红蛋白电泳来排除地中海贫血特质的患者人数要少得多:结论:尽管大多数贫血儿童都是继发性缺铁,但所有贫血患者都应测定门采尔指数,以避免在地中海贫血特质的情况下不慎开出补铁处方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HAEMATOLOGICAL PROFILE AND MENTZER INDEX IN PEDIATRIC PATIENTS PRESENTING WITH ANEMIA
Objective: The objective of this study was to analyze clinical and hematological profile of children with anemia and determine the Mentzer index of all cases presenting with anemia. Methods: This was a cross-sectional observational study conducted in the Department of pediatrics of a tertiary care medical college. Eighty pediatric age group patients diagnosed to be having anemia on clinical examination were included in this study. Demographic details such as age and gender were noted in all cases. A through history was obtained and a clinical examination was done. Presenting complaints were also noted. Complete blood count with peripheral blood smear examination was done in all cases. The Mentzer index was determined from complete blood count reports. Results: Out of 80 studied cases, there were 57 (71.25%) boys and 23 (28.75%) girls. The mean age for boys was 9.12±3.14 years and for girls, it was slightly higher at 10.24±3.46 years. Fatigue (73.75%), pallor (71.25%), and anorexia (56.25%) were common complaints. About 55% had mild anemia 22.5% had moderate anemia and 22.5% suffered from severe. Mean hemoglobin concentration of studied cases was found to be 8.42±3.98 g/dL. The most prevalent blood picture was the normocytic normochromic blood picture, representing 60% of cases. Mentzer index ranged from a minimum of 10.83 to a maximum of 27.76, with the mean value being 17.40±2.92. Notably, the vast majority of patients (97.5%) had a Mentzer Index >13, suggesting a high prevalence of iron deficiency. Conversely, only 2.5% of the patients had a Mentzer Index at or below 13, indicating a much smaller subset in whom Hb electrophoresis was needed to rule out thalassemia trait. Conclusion: Although most of the children with anemia are secondary to iron deficiency Mentzer index should be determined in all patients of anemia so as to avoid inadvertently prescribing iron supplementation in cases of thalassemia trait.
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