利用红龙果皮（hylocereus polyrhizus）乙醇提取物口服薄膜条作为口腔清新剂

Q2 Pharmacology, Toxicology and Pharmaceutics

International Journal of Applied Pharmaceutics Pub Date : 2024-05-07 DOI:10.22159/ijap.2024v16i3.50043

Nabila Apriliani, L. Laila, B. Prasetyo

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引用次数: 0

摘要

研究目的本研究旨在配制含有红龙果皮乙醇提取物（Hylocereus polyrhizus）的口服薄膜条（OTFS），并评估其特性、稳定性和对变异链球菌（S. mutans）的抗菌活性：方法：采用溶剂浇注法，加入不同浓度的红龙果皮乙醇提取物（5%、10% 和 15%）制成薄膜。对薄膜的感官测试、重量、厚度、pH 值、崩解时间、耐折度、稳定性测试和抗菌活性进行了评估：结果表明，薄膜具有独特的颜色、香气和提取物的味道。薄膜的重量在 0.07-0.21 克之间，厚度在 0.10-0.20 毫米之间，pH 值在 5.70-5.99 之间，崩解时间在 34.99-49.13 秒之间，耐折度在 321.00-812.83 次之间。薄膜在不同的贮藏温度（4±2 ℃、28±2 ℃和 40±2 ℃）下稳定贮藏 2 个月。5%、10%和 15%的薄膜具有抗菌活性，抑菌直径分别为 8.5 毫米、10.8 毫米和 12.9 毫米：结论：RDFP 的乙醇提取物可用作口腔清新剂薄膜，该薄膜可稳定使用 2 个月，并对变异杆菌具有抗菌活性。

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UTILIZATION RED DRAGON FRUIT PEEL (HYLOCEREUS POLYRHIZUS) ETHANOL EXTRACT IN ORAL THIN FILM STRIP AS A MOUTH FRESHENER

Objective: The aim of this study was to formulate an oral thin film strip (OTFS) contained the red dragon fruit peel (RDFP) ethanol extract (Hylocereus polyrhizus) and evaluate the characteristic, stability and antibacterial activity against Streptococcus mutans (S. mutans). Methods: The film was made using the solvent casting method by adding a variety of concentration ethanol extract of red dragon fruit peel (5%, 10%, and 15%). The films were evaluated in organoleptic test, weight, thickness, pH, disintegration time, folding endurance, stability test and antibacterial activity. Results: The results showed that the film provided a distinctive color, aroma, and taste of the extract. The result of film evaluation had weight between 0.07-0.21 g, thickness between 0.10-0.20 mm, pH between 5.70-5.99, disintegration time between 34.99-49.13 s, and folding endurance between 321.00-812.83 times. The films were stable for 2 mo at a variety storage temperature (4±2 ℃, 28±2 ℃, and 40±2 ℃). The films showed antibacterial activity for 5%, 10% and 15% with the diameter of inhibition 8.5 mm, 10.8 mm, and 12.9 mm, respectively. Conclusion: Ethanol extract of RDFP can be utilized as a mouth freshener film that is stable for 2 mo and has antibacterial activity against S. mutans.

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来源期刊

International Journal of Applied Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

219

期刊介绍： International Journal of Applied Pharmaceutics (Int J App Pharm) is a peer-reviewed, bimonthly (onward March 2017) open access journal devoted to the excellence and research in the pure pharmaceutics. This Journal publishes original research work that contributes significantly to further the scientific knowledge in conventional dosage forms, formulation development and characterization, controlled and novel drug delivery, biopharmaceutics, pharmacokinetics, molecular drug design, polymer-based drug delivery, nanotechnology, nanocarrier based drug delivery, novel routes and modes of delivery; responsive delivery systems, prodrug design, development and characterization of the targeted drug delivery systems, ligand carrier interactions etc. However, the other areas which are related to the pharmaceutics are also entertained includes physical pharmacy and API (active pharmaceutical ingredients) analysis. The Journal publishes original research work either as a Original Article or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication in the Journal.