代谢综合征与非酒精性脂肪肝的关系

Shweta Jain, Biswas Ss, Swati Jain
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摘要

目的:非酒精性脂肪肝与肝脏脂肪浸润和内脏肥胖密切相关,因此是代谢综合征的原因和结果。本研究旨在发现代谢综合征(MetS)与非酒精性脂肪肝(NAFLD)之间的关联:方法:共选取 342 名受试者进行为期一年的研究,其中 86 名为非酒精性脂肪肝患者,86 名为对照组。非酒精性脂肪肝的诊断是通过肝脏成像和肝酶进行的。MetS 评估是根据国家胆固醇教育计划成人治疗小组 III(NCEP ATP III)标准进行的。所有生化指标、血液指标和肝酶的估算均按照标准指南进行。采用单因素方差分析对不同组的定量数据进行平均比较:结果:与对照组相比,非酒精性脂肪肝患者的体重指数、腰围和血脂水平明显偏高(P<0.001)。根据 NCEP ATP III 标准,59.3% 的非酒精性脂肪肝患者伴有 MetS,其风险估计值显著(几率比=2.15):本研究表明,在非酒精性脂肪肝病例中,MetS 的所有成分都有所增加,生化指标也发生了严重变化。因此,只要在临床检查中发现 MetS 因素,就必须通过影像学检查(脂肪肝)诊断患者是否患有非酒精性脂肪肝。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
AN ASSOCIATION OF METABOLIC SYNDROME WITH NONALCOHOLIC FATTY LIVER DISEASE
Objectives: Nonalcoholic fatty liver disease is strongly linked with hepatic fatty infiltration and visceral adiposity, therefore, being a cause and a result of metabolic syndrome. The objective of the study is to find an association of metabolic syndrome (MetS) with nonalcoholic fatty liver disease (NAFLD). Methods: A total of 342 subjects from which 86 NAFLD 86 control were suitably selected for study duration of 1 year. Diagnosis of nonalcoholic fatty liver disease was done by liver imaging and based on liver enzymes. MetS assessment was done by the national cholesterol education program adult treatment panel III (NCEP ATP III) criteria. Estimation of all biochemical and hematological parameters and liver enzymes was done following standard guidelines. Mean comparison of quantitative data in different groups was analyzed with one-way analysis of variance. Results: There were significant high levels of body mass index, waist circumference, and lipid profiles in NAFLD patients in comparison to control population (p<0.001). According to the NCEP ATP III criteria, 59.3% of NAFLD were present with MetS where risk estimate was significant (odds ratio=2.15). Conclusion: This study suggests that there is an increased in all the components of MetS and gross changes in biochemical markers in cases of NAFLD. Therefore, whenever MetS factors are met in the clinical checkups, patients must be diagnosed for NAFLD by imaging (fatty liver).
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