树突状细胞疫苗:应对 SARS-CoV-2 大流行的潜在有效策略

Yichun Wang
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摘要

严重急性呼吸系统综合症冠状病毒 2(SARS-CoV-2)的演变仍然难以预测,在传统疫苗可能不足以应对各地的 SARS-CoV-2 变种的情况下,迫切需要新的有效疫苗来缓解大流行。树突状细胞(DC)疫苗是一种新型癌症免疫疗法,在单独或与其他干预措施相结合的临床试验中取得了良好的效果。由于其强大的免疫激活能力和现有研究发现的相关靶点,有望成为抗击 SARS-CoV-2 感染的一种新的免疫疗法。本文讨论了树突状细胞在免疫系统中的作用机制及其在癌症治疗中的策略,并分析了树突状细胞疫苗在应对SARS-CoV-2感染中的作用,比较了现有疫苗类型的优缺点,以探讨树突状细胞疫苗作为应对SARS-CoV-2大流行的有效策略的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dendritic cell vaccines: A potentially effective strategy for the SARS-CoV-2 pandemic
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unpredictable, and there is an urgent need for new and effective vaccines to mitigate the pandemic at a time when traditional vaccines may not be sufficient to deal with SARS-CoV-2 variants everywhere. The dendritic cell (DC) vaccine, a novel cancer immunotherapy, has achieved good results in clinical trials alone or combination with other interventions. Due to its strong immune activation ability and the relevant targets found by existing studies, it is expected to become a new immunotherapy against SARS-CoV-2 infection. This article discusses the mechanism of dendritic cells in the immune system and its strategies in cancer treatment, as well as analyzes the role of dendritic cell vaccines in coping with SARS-CoV-2 infection, and compares the advantages and disadvantages of existing vaccine types, in order to explore the possibility of dendritic cell vaccines as an effective strategy against the SARS-CoV-2 pandemic.
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