{"title":"植物药提取物和化合物的抗辐射性能综述","authors":"Mwalimu Raphael Jilani, Azhagu Saravana Babu Packirisamy","doi":"10.22159/ajpcr.2024.v17i5.50248","DOIUrl":null,"url":null,"abstract":"Humans are routinely exposed to radiation when receiving cancer treatment, fighting nuclear weapons, exploring space, and flying. Radiation exposure damages biological components such as protein, lipids, and cell membranes because it causes oxidative stress and inflammatory mediators, which can lead to DNA destruction even at low concentrations. Protecting people from the harmful effects of radiation is a challenging task due to the plethora of side effects of the chemical compounds used to mitigate DNA damage in normal cells. Hospitals continue to utilize radiotherapy for cancer treatment; yet, the adverse effects of the radiation they emit have outweighed the benefits. Plant phytochemicals and their derivatives exhibit diverse biological functions, often perceived as innocuous due to their non-toxic nature within subcellular and cellular environments. Moreover, they possess the capability to mitigate radiation-induced damage. This review aims to delineate the radioprotective attributes of plant polyphenols and extracts, elucidating their mechanisms of action across various models.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"170 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"REVIEW OF PHYTO-MEDICAL EXTRACTS’ AND COMPOUNDS’ ANTI-RADIATION PROPERTIES\",\"authors\":\"Mwalimu Raphael Jilani, Azhagu Saravana Babu Packirisamy\",\"doi\":\"10.22159/ajpcr.2024.v17i5.50248\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Humans are routinely exposed to radiation when receiving cancer treatment, fighting nuclear weapons, exploring space, and flying. Radiation exposure damages biological components such as protein, lipids, and cell membranes because it causes oxidative stress and inflammatory mediators, which can lead to DNA destruction even at low concentrations. Protecting people from the harmful effects of radiation is a challenging task due to the plethora of side effects of the chemical compounds used to mitigate DNA damage in normal cells. Hospitals continue to utilize radiotherapy for cancer treatment; yet, the adverse effects of the radiation they emit have outweighed the benefits. Plant phytochemicals and their derivatives exhibit diverse biological functions, often perceived as innocuous due to their non-toxic nature within subcellular and cellular environments. Moreover, they possess the capability to mitigate radiation-induced damage. This review aims to delineate the radioprotective attributes of plant polyphenols and extracts, elucidating their mechanisms of action across various models.\",\"PeriodicalId\":504156,\"journal\":{\"name\":\"Asian Journal of Pharmaceutical and Clinical Research\",\"volume\":\"170 4\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Pharmaceutical and Clinical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22159/ajpcr.2024.v17i5.50248\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Pharmaceutical and Clinical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22159/ajpcr.2024.v17i5.50248","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
人类在接受癌症治疗、对抗核武器、探索太空和飞行时经常受到辐射。辐照会破坏蛋白质、脂质和细胞膜等生物成分,因为它会导致氧化应激和炎症介质,即使浓度很低也会导致 DNA 破坏。由于用于减轻正常细胞 DNA 损伤的化学物质会产生大量副作用,因此保护人们免受辐射的有害影响是一项具有挑战性的任务。医院仍在使用放射疗法治疗癌症,但其放射线的负面影响已超过了其带来的益处。植物营养素及其衍生物具有多种生物功能,由于在亚细胞和细胞环境中无毒,通常被认为是无害的。此外,它们还具有减轻辐射引起的损伤的能力。本综述旨在描述植物多酚和提取物的辐射防护特性,阐明它们在各种模型中的作用机制。
REVIEW OF PHYTO-MEDICAL EXTRACTS’ AND COMPOUNDS’ ANTI-RADIATION PROPERTIES
Humans are routinely exposed to radiation when receiving cancer treatment, fighting nuclear weapons, exploring space, and flying. Radiation exposure damages biological components such as protein, lipids, and cell membranes because it causes oxidative stress and inflammatory mediators, which can lead to DNA destruction even at low concentrations. Protecting people from the harmful effects of radiation is a challenging task due to the plethora of side effects of the chemical compounds used to mitigate DNA damage in normal cells. Hospitals continue to utilize radiotherapy for cancer treatment; yet, the adverse effects of the radiation they emit have outweighed the benefits. Plant phytochemicals and their derivatives exhibit diverse biological functions, often perceived as innocuous due to their non-toxic nature within subcellular and cellular environments. Moreover, they possess the capability to mitigate radiation-induced damage. This review aims to delineate the radioprotective attributes of plant polyphenols and extracts, elucidating their mechanisms of action across various models.