胰酶替代物对营养不良儿童人体测量参数的治疗效果：试点临床试验

IF 0.4 4区医学 Q4 PEDIATRICS

Iranian Journal of Pediatrics Pub Date : 2024-05-11 DOI:10.5812/ijp-146634

Setila Dalili, Shohreh Maleknejad, Tara Asgharpour, Soodeh Salehi, Marjan Mahdavi-Roshan, Afagh Hassanzadeh Rad

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引用次数: 0

摘要

背景：营养不良是全球健康面临的一项重大挑战，需要制定创新的治疗策略。研究目的本研究探讨了胰酶对改善中重度营养不良儿童生长指标的治疗效果。研究方法在这项临床试验中，在消化内科诊所就诊的2至14岁生长障碍患者（Z-score体重低于-2）被随机分配到两组：胰酶替代疗法组（PERT）和对照组。试验包括一项试点研究，每组 30 名受试者。胰酶替代疗法组接受为期 2 个月的治疗，在主要三餐中服用 1000 U/kg胰酶，并辅以营养计划。相比之下，对照组则服用矿物质补充剂，并遵循常规饮食。干预前后记录了人口统计学数据和人体测量指数，包括身高、体重、体重指数（BMI）和 Z 评分。结果在本研究中，PERT 组生长障碍儿童的体重、身高、体重指数和食欲的平均值在干预前后有显著的统计学差异。然而，PERT 组与对照组的平均值在统计学上没有明显差异。结论：本研究结果表明，胰酶对改善营养不良儿童生长参数的治疗效果在统计学上并不显著。今后有必要进行规模更大、疗程更长的随机试验。

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The Therapeutic Effect of Pancreatic Enzyme Replacement on Anthropometric Parameters in Children with Malnutrition: A Pilot Clinical Trial

Background: Malnutrition presents a significant global health challenge, necessitating the creation of innovative treatment strategies. Objectives: This study explored the therapeutic impact of pancreatic enzymes on improving growth indicators in children suffering from moderate to severe malnutrition. Methods: In this clinical trial, patients aged 2 to 14 years with growth disorders (Z-score weight below -2) attending a Gastroenterology Clinic were randomly assigned to two groups: Pancreatic enzyme replacement therapy (PERT) and control. The trial involved a pilot study with 30 subjects in each group. The PERT group underwent a 2-month treatment regimen of 1000 U/kg pancreatic enzymes taken with the main three meals, complemented by a nutritional plan. In contrast, the Control group received mineral supplements and followed a regular diet. Demographic data and anthropometric indices, including height, weight, body mass index (BMI), and Z scores, were recorded before and after the intervention. Results: In this study, a statistically significant difference was observed in the mean values of weight, height, BMI, and appetite among children with growth disorders in the PERT group before and after the intervention. However, no statistically significant difference was found between the mean values in the PERT group and the control group. Conclusions: The results of this study suggest that the therapeutic effect of pancreatic enzymes on improving growth parameters in malnourished children was not statistically significant. Future randomized trials on a larger scale with longer treatment durations are warranted.

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来源期刊

Iranian Journal of Pediatrics 医学-小儿科

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.