肠系膜利奥米肉瘤肝转移患者的孤立肝脏化学灌注疗法

Q4 Medicine
I. V. Reshetov, V. Manukovsky, A. Demko, V. Cheremisov, A. V. Osipov, S. S. Taniya, M. A. Privalov, A. I. Babich
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引用次数: 0

摘要

背景。无法手术的继发性肝癌的治疗仍然具有挑战性,尤其是结直肠癌患者。传统的全身药物治疗往往效果不佳,经动脉化疗栓塞术的使用也因某些药物的全身毒性而受到限制。孤立化疗灌注兼具疗效高和全身毒性低的特点,是肝转移患者的一种很有前景的治疗选择。病例报告。一名肠系膜白肌瘤患者接受了多次手术和化疗,但肝转移灶仍在继续生长。在切除肝段并移除肝脏血管后,患者接受了美法仑孤立肝化疗灌注。为了缩小肿瘤体积和预防并发症,还进行了非典型肝切除术。结论孤立肝脏化学灌注治疗肝癌仍是一个争论的话题,并没有被纳入原发性和转移性肝脏肿瘤的治疗标准中。事实证明,这种技术在治疗细肌瘤肝转移方面是安全和有前景的。然而,还需要进一步的研究来评估这种方法在总体生存率方面的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isolated liver chemoperfusion in a patient with mesenteric leiomyosarcoma and liver metastasis
Background. Treatment for inoperable secondary liver cancer remains challenging especially in patients with colorectal cancer. Traditional systemic drug therapy is often ineffective, and the use of transarterial chemoembolization is limited due to the systemic toxicity of some drugs. Combining high efficacy and low systemic toxicity, isolated chemoperfusion is a promising treatment option for patients with liver metastasis. Case report. A patient with mesentery leiomyosarcoma underwent several surgeries and chemotherapy courses, but liver metastases continued to grow. Isolated liver chemoperfusion with melphalan was performed after resection of liver segment and mobilization of liver vessels. To reduce the tumor volume and prevent complications, atypical liver resection was also performed. Conclusion. Isolated liver chemoperfusion for the treatment of liver cancer remains a subject of debate and is not included in the standards for treatment of primary and metastatic liver tumors. This technique was shown to be safe and promising in treating liver metastasis from leiomyosarcoma. However, further research is required to assess the role of this procedure in overall survival.
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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