非小细胞肺癌患者小支气管和大支气管粘膜形态变化的对比分析

Q4 Medicine
O. Pankova, V. Perelmuter, D. Pismenny, A. Fedorov, D. Loos, E. Rodionov, M. Zavyalova, S. Miller
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引用次数: 0

摘要

背景。尽管手术和治疗技术不断进步,但非小细胞肺癌(NSCLC)仍是最常见的癌症之一,也是导致癌症相关死亡的主要原因。因此,寻找能预测肿瘤进展风险的标志物变得越来越重要。对不同口径支气管上皮细胞形态的研究具有解决这一问题的巨大潜力。本研究旨在比较评估肺鳞状细胞癌和肺腺癌患者大、小口径支气管上皮各种形态变化组合的特征和发生频率。材料和方法:收集了在 TNRMC 癌症研究所接受手术的 151 名 NSCLC 患者(T1-4N0-3M0 期)的肺部样本。分析支气管上皮细胞的各种形态变化。结果对小口径支气管各种形态变化发生频率的研究显示,90.8%的病例发生了基底细胞增生。33.8%的病例出现弥漫性孤立基底细胞增生。38.4%的病例被诊断为局灶性基底细胞增生。18.5%的病例合并有基底细胞增生和鳞状化生。对大口径支气管发病频率的研究表明,基底细胞增生是最常见的形态变异(93.4%,包括弥漫孤立性基底细胞增生(33.8%)和局灶性基底细胞增生(38.4%))。19.8%的患者合并有基底细胞增生和鳞状化生。与小口径支气管上皮相比,发现基底细胞增生、鳞状化生和发育不良的比例为 1.3%。结论关于大口径支气管形态变化发生频率的研究结果对进一步研究确定非小细胞肺癌高危人群具有理论意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative analysis of morphological changes in the mucosa of the small and large bronchi in non-small cell lung cancer
Background. Despite advances in surgical and therapy techniques, non-small cell lung cancer (NSCLC) is one of the most common cancers and the leading cause of cancer-related death. Therefore, it is increasingly important to search for markers that predict the risk of tumor progression. The study of the morphology of the epithelium of the bronchi of different calibers has great potential for solving this problem. The aim of the study was to comparatively evaluate the characteristics and frequency of occurrence of various combinations of morphological changes in the epithelium of the bronchi of large and small calibers in patients with lung squamous cell carcinoma and lung adenocarcinoma. Material and methods. lung samples were collected from 151 NSCLC patients (stage T1–4N0–3M0), who underwent surgery at the cancer Research institute, TNRMC. Various morphological changes in the bronchial epithelium were analyzed. Results. The study of the frequency of occurrence of various morphological changes in small-caliber bronchi showed that basal cell hyperplasia occurred in 90.8 % of cases. Diffuse isolated basal cell hyperplasia was observed in 33.8 % of cases. Focal basal cell hyperplasia was diagnosed in 38.4 % of cases. A combination of basal cell hyperplasia with squamous metaplasia was observed in 18.5 % of cases. The study of the frequency of occurrence in large-caliber bronchi demonstrated that basal cell hyperplasia was the most common morphological variant (93.4 %, including diffuse isolated basal cell hyperplasia in 33.8 % and focal basal cell hyperplasia in 38.4 %). The combination of basal cell hyperplasia and squamous metaplasia was found in 19.8 %. The combination of basal cell hyperplasia with squamous metaplasia and dysplasia was found in 1.3 % compared to the epithelium of small-caliber bronchi. Conclusion. The obtained results on the frequency of occurrence of morphological changes in large-caliber bronchi are of theoretical interest for further research to identify groups at high risk of progression of non-small cell lung cancer.
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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