约翰-坎宁安病毒与进行性多灶性白质脑病:误诊

Diseases Pub Date : 2024-05-13 DOI:10.3390/diseases12050100
Dimitra S. Mouliou
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引用次数: 0

摘要

进行性多灶性白质脑病(PML)是一种可能致命的脱髓鞘疾病,约翰-坎宁安多瘤病毒(JCPyV)被认为是这种疾病的病因。所谓的 JCPyV 最初是在淋巴瘤和人类免疫缺陷病毒(HIV)病例中报告的,而如今,在接受纳他珠单抗(泰萨布瑞)治疗的多发性硬化症(MS)病例中,其发病率正在上升。然而,关于其病理和诊断的文献数据相互矛盾,同时还存在一些误诊报告,从而引发了对这一主题的进一步质疑。实际上,所谓的 PML 和假定的 JCPyV 并不像它们看起来那样。此外,可能会有新的、更频繁的 PML 类病症报告,尤其是在 2019 年冠状病毒病(COVID-19)大流行之后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis
Progressive Multifocal Leukoencephalopathy (PML) is a possibly fatal demyelinating disease and John Cunningham Polyomavirus (JCPyV) is believed to cause this condition. The so-called JCPyV was initially reported in lymphoma and Human Immunodeficiency Virus (HIV) cases, whereas nowadays, its incidence is increasing in Multiple Sclerosis (MS) cases treated with natalizumab (Tysabri). However, there are conflicting literature data on its pathology and diagnosis, whereas some misdiagnosed reports exist, giving rise to further questions towards the topic. In reality, the so-called PML and the supposed JCPyV are not what they seem to be. In addition, novel and more frequent PML-like conditions may be reported, especially after the Coronavirus Disease 2019 (COVID-19) pandemic.
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