印度中部立克次体感染的前瞻性研究

D. Taraphdar, R. Hawaldar, S. Sodani
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引用次数: 0

摘要

立克次体感染在印度报告不足。由于大多采用非特异性血清学检测来诊断这些感染,因此实际的疾病负担被低估了。本研究的目的是通过实时聚合酶链式反应检测临床样本中的立克次体感染。研究旨在分析不明原因热病(PUO)或未分化热病例的血液样本。在 2021 年 10 月至 2023 年 5 月期间,共有 69 名此类患者被转诊到印度印多尔的诊断中心。在检测的样本中,14 名患者(20.3%)的立克次体感染呈阳性。儿童是感染的主要人群(占病例的 50%);虽然严重程度不高,但他们也有多重感染。一些患者还出现了严重的临床表现,包括住院治疗。印度关于立克次体感染分子诊断的报告很少。早期分子诊断有助于避免和预防严重的并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A prospective study on Rickettsia infections in Central India
Rickettsial infections are under-reported in India. The actual disease burden has been underestimated as non-specific serological tests are mostly used to diagnose these infections. The aim of this study was the detection of Rickettsia infections in clinical specimens by Real-time Polymerase Chain Reaction.A study was established to analyse blood samples taken from pyrexia of unknown origin (PUO) or undifferentiated fever cases. A total of 69 such patients, were referred/walked-in to our diagnostic centre, Indore, India between October 2021 and May 2023. The blood samples were collected in EDTA lavender (purple) top tube.Of the tested samples, 14 patients (20.3%) were positive for Rickettsia infection.Gender wise distribution revealed higher incidence (57%) of Rickettsial infections in male patients. Children were majorly infected (50% of cases); multiple infection was also noted in them, though severity was not high. Severe clinical manifestation including hospitalization was also noted in some patients. Few reports are available from India on molecular diagnosis of Rickettsia infection. Early-stage molecular diagnosis will help to stave off and prevent serious complications. 
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