男同性恋者持续性全身性淋巴结病综合征的流式细胞淋巴细胞免疫分型:淋巴结和血液的纵向研究。

Diagnostic and clinical immunology Pub Date : 1987-01-01
R R Turner, D C Boone, A M Levine, P W Nichols, J W Parker
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引用次数: 0

摘要

我们对11例持续性全身性淋巴结病(PGL)综合征患者的一系列淋巴结活检和外周血样本进行了淋巴细胞表型分析,并将结果与组织学和临床表现(中位随访18个月)相关联,以寻找可能预测获得性免疫缺陷综合征(AIDS)演变的因素。后续淋巴结活检显示,OKT4+和OKT8+表型的t细胞百分比较高,Slg+ b细胞和OKla+细胞百分比较低。与相似时间间隔内观察到的进行性外周血OKT4+淋巴细胞减少相比,淋巴结变化程度相对较小。一名恶性淋巴瘤患者淋巴结t细胞百分比高,外周血t细胞计数低。我们的结论是,一系列淋巴结研究有助于了解PGL的自然史,但外周血计数是个体患者免疫状态的更敏感指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Flow cytometric lymphocyte immunophenotyping in homosexual men with the persistent generalized lymphadenopathy syndrome: a longitudinal study of lymph nodes and blood.

We have performed lymphocyte phenotypic analysis on serial lymph node biopsies and peripheral blood samples from 11 patients with the persistent generalized lymphadenopathy (PGL) syndrome and correlated the findings with histologic and clinical findings (median follow-up 18 months) in a search for factors that may predict evolution to acquired immunodeficiency syndrome (AIDS). Follow-up lymph node biopsies showed higher percentages of T-cells, both OKT4+ and OKT8+ phenotypes, and lower percentages of Slg+ B-cells and OKla+ cells. The lymph node changes were relatively minor in degree compared to the progressive peripheral blood OKT4+ lymphocytopenia observed over a similar time interval. The one patient who developed a malignant lymphoma had a high percentage of nodal T-cells and low peripheral blood T-cell counts. We conclude that serial lymph node studies contribute to an understanding of the natural history of PGL, but that peripheral blood counts are a more sensitive indicator of immune status in individual patients.

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