解密 PHD 手指蛋白从致癌驱动因子到肿瘤抑制因子的双重作用

Tingyu Fan, Lai Jiang, Xuancheng Zhou, Hao Chi, Xi Zeng
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引用次数: 0

摘要

PHD(植物同源结构域)指蛋白是癌症生物学中的核心表观遗传读取器和调节器,协调着对肿瘤发生和抑制至关重要的一系列细胞过程。这篇综述描述了 PHD 手指在癌症中的双重作用,强调它们参与染色质重塑、基因表达调控以及与细胞信号网络的相互作用。PHD 手指解读特定组蛋白修饰的能力突出表明了它们对基因表达模式的影响,从而对细胞增殖、DNA 修复和细胞凋亡等关键的癌症相关过程产生影响。这篇综述深入探讨了某些 PHD 手指蛋白的致癌潜能,以 PHF1 和 PHF8 为例,它们通过表观遗传失调以及对 Wnt 和 TGFβ 等信号通路的调节来促进肿瘤进展。相反,综述还讨论了 PHD 手指蛋白(如 PHF2 和 ING 家族成员)的抑制肿瘤功能,它们通过与染色质和转录调节因子的相互作用,维护基因组稳定性并抑制肿瘤生长。此外,考虑到 PHD 手指蛋白在调控癌症干细胞和影响癌症治疗的免疫反应方面的关键作用,该综述还探讨了在癌症治疗中靶向 PHD 手指蛋白的治疗潜力。这篇综述全面综述了目前的研究成果,强调了 PHD 手指蛋白在癌症生物学中的复杂而又充满希望的前景,提倡进一步开展研究,利用其独特的细胞作用开辟新的治疗途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Deciphering the dual roles of PHD finger proteins from oncogenic drivers to tumor suppressors
PHD (plant homeodomain) finger proteins emerge as central epigenetic readers and modulators in cancer biology, orchestrating a broad spectrum of cellular processes pivotal to oncogenesis and tumor suppression. This review delineates the dualistic roles of PHD fingers in cancer, highlighting their involvement in chromatin remodeling, gene expression regulation, and interactions with cellular signaling networks. PHD fingers’ ability to interpret specific histone modifications underscores their influence on gene expression patterns, impacting crucial cancer-related processes such as cell proliferation, DNA repair, and apoptosis. The review delves into the oncogenic potential of certain PHD finger proteins, exemplified by PHF1 and PHF8, which promote tumor progression through epigenetic dysregulation and modulation of signaling pathways like Wnt and TGFβ. Conversely, it discusses the tumor-suppressive functions of PHD finger proteins, such as PHF2 and members of the ING family, which uphold genomic stability and inhibit tumor growth through their interactions with chromatin and transcriptional regulators. Additionally, the review explores the therapeutic potential of targeting PHD finger proteins in cancer treatment, considering their pivotal roles in regulating cancer stem cells and influencing the immune response to cancer therapy. Through a comprehensive synthesis of current insights, this review underscores the complex but promising landscape of PHD finger proteins in cancer biology, advocating for further research to unlock novel therapeutic avenues that leverage their unique cellular roles.
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